TY  - JOUR
AU  - Lacal, Juan Carlos
AU  - Zimmerman, Tahl
AU  - Campos, Joaquín M.
PY  - 2021
DO  - 10.3390/pharmaceutics13060788
UR  - http://hdl.handle.net/10668/4203
T2  - Pharmaceutics
AB  - Choline kinase (ChoK) is a cytosolic enzyme that catalyzes the phosphorylation of choline to form phosphorylcholine (PCho) in the presence of ATP and magnesium. ChoK is required for the synthesis of key membrane phospholipids and is involved in...
LA  - en
PB  - MDPI
KW  - Phospholipids metabolism
KW  - Choline kinase
KW  - Bispyridinium compounds
KW  - Bisquinolinium compounds
KW  - QSAR
KW  - Anticancer drugs
KW  - Rheumatoid arthritis
KW  - Parasites
KW  - Pathogenic bacteria
KW  - Inflammatory disease
KW  - Phosphorylation
KW  - Colina quinasa
KW  - Relación estructura-actividad cuantitativa
KW  - Antineoplásicos
KW  - Artritis reumatoide
KW  - Parásitos
KW  - Fosforilcolina
KW  - Fosforilación
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
KW  - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Choline Kinase
KW  - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amines::Quaternary Ammonium Compounds::Trimethyl Ammonium Compounds::Choline::Phosphorylcholine
KW  - Medical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Elements::Metals, Alkaline Earth::Magnesium
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Invertebrates::Parasites
KW  - Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Structure-Activity Relationship::Quantitative Structure-Activity Relationship
KW  - Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Phosphorylation
KW  - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic Agents
KW  - Medical Subject Headings::Diseases::Neoplasms
KW  - Medical Subject Headings::Diseases::Musculoskeletal Diseases::Rheumatic Diseases::Arthritis, Rheumatoid
KW  - Medical Subject Headings::Chemicals and Drugs::Lipids::Phospholipids
KW  - Medical Subject Headings::Organisms::Bacteria
KW  - Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Purines::Purine Nucleotides::Adenine Nucleotides::Adenosine Triphosphate
TI  - Choline Kinase: An Unexpected Journey for a Precision Medicine Strategy in Human Diseases
TY  - review article
ER  -