RT Journal Article
T1 Satellite glia of the adult dorsal root ganglia harbor stem cells that yield glia under physiological conditions and neurons in response to injury.
A1 Maniglier, Madlyne
A1 Vidal, Marie
A1 Bachelin, Corinne
A1 Deboux, Cyrille
A1 Chazot, Jérémy
A1 Garcia-Diaz, Beatriz
A1 Baron-Van Evercooren, Anne
K1 CNS
K1 DRG
K1 injury
K1 peripheral nerve
K1 satellite glial cells
K1 spinal cord
K1 stem cells
AB The presence of putative stem/progenitor cells has been suggested in adult peripheral nervous system (PNS) tissue, including the dorsal root ganglion (DRG). To date, their identification and fate in pathophysiological conditions have not been addressed. Combining multiple in vitro and in vivo approaches, we identified the presence of stem cells in the adult DRG satellite glial population, and progenitors were present in the DRGs and sciatic nerve. Cell-specific transgenic mouse lines highlighted the proliferative potential of DRG stem cells and progenitors in vitro. DRG stem cells had gliogenic and neurogenic potentials, whereas progenitors were essentially gliogenic. Lineage tracing showed that, under physiological conditions, adult DRG stem cells maintained DRG homeostasis by supplying satellite glia. Under pathological conditions, adult DRG stem cells replaced DRG neurons lost to injury in addition of renewing the satellite glial pool. These novel findings open new avenues for development of therapeutic strategies targeting DRG stem cells for PNS disorders.
YR 2022
FD 2022
LK http://hdl.handle.net/10668/22526
UL http://hdl.handle.net/10668/22526
LA en
DS RISalud
RD Apr 19, 2025