%0 Journal Article
%A Molina, Juan
%A Navas, Ana
%A Agüera, María-Luisa
%A Rodelo-Haad, Cristian
%A Alonso, Corona
%A Rodríguez-Benot, Alberto
%A Aljama, Pedro
%A Solana, Rafael
%T Impact of Preformed Donor-Specific Anti-Human Leukocyte Antigen Antibody C1q-Binding Ability on Kidney Allograft Outcome.
%D 2017
%@ 1664-3224
%U https://hdl.handle.net/10668/25798
%X The consolidation of single antigen beads (SAB-panIgG) assay in the detection of preformed anti-human leukocyte antigen (HLA) antibodies has improved transplantation success. However, its high sensitivity has limited the allograft allocation for sensitized patients, increasing their waiting time. A modification of the standard SAB-panIgG assay allows the detection of that subset of antibodies capable of binding C1q (SAB-C1q assay). However, the clinical usefulness of SAB-C1q assay for determining the unacceptable mismatches is under discussion. We retrospectively analyzed the impact of preformed donor-specific anti-HLA antibodies (DSA) according to the C1q-binding ability on allograft outcome, examining 389 single-kidney transplanted patients from deceased donors. Recipients with preformed C1q-binding DSA showed the lowest allograft survival up to 7 years (40.7%) compared to patients with preformed non-C1q-binding DSA (73.4%; p = 0.001) and without DSA (79.1%; p 
%K C1q-binding antibodies
%K allograft-loss risk
%K kidney allograft survival
%K kidney transplantation
%K preformed anti-HLA antibodies
%K single antigen beads assay
%~