RT Journal Article
T1 Prior Treatment with Statins is Associated with Improved Outcomes of Patients with COVID-19: Data from the SEMI-COVID-19 Registry.
A1 Torres-Peña, José David
A1 Pérez-Belmonte, Luis M
A1 Fuentes-Jiménez, Francisco
A1 López Carmona, Mª Dolores
A1 Pérez-Martinez, Pablo
A1 López-Miranda, José
A1 Carrasco Sánchez, Francisco Javier
A1 Vargas Núñez, Juan Antonio
A1 Del Corral Beamonte, Esther
A1 Magallanes Gamboa, Jeffrey Oskar
A1 González García, Andrés
A1 González Moraleja, Julio
A1 Cortés Troncoso, Andrés
A1 Taboada Martínez, María Luisa
A1 Del Fidalgo Montero, María Del Pilar
A1 Seguí Ripol, José Miguel
A1 Gil Sánchez, Ricardo
A1 Alegre González, Diana
A1 Boixeda, Ramon
A1 Cortés Rodríguez, Begoña
A1 Ena, Javier
A1 García García, Gema María
A1 Ventura Esteve, Ana
A1 Ramos Rincón, José Manuel
A1 Gómez-Huelgas, Ricardo
A1 SEMI-COVID-19 Network, 
AB The impact of statins on COVID-19 outcomes is important given the high prevalence of their use among individuals at risk for severe COVID-19. Our aim is to assess whether patients receiving chronic statin treatment who are hospitalized with COVID-19 have reduced in-hospital mortality if statin therapy is maintained during hospitalization. This work is a cross-sectional, observational, retrospective multicenter study that analyzed 2921 patients who required hospital admission at 150 Spanish centers included in the nationwide SEMI-COVID-19 Network. We compared the clinical characteristics and COVID-19 disease outcomes between patients receiving chronic statin therapy who maintained this therapy during hospitalization versus those who did not. Propensity score matching was used to match each statin user whose therapy was maintained during hospitalization to a statin user whose therapy was withdrawn during hospitalization. After propensity score matching, continuation of statin therapy was associated with lower all-cause mortality (OR 0.67, 0.54-0.83, p  Patients previously treated with statins who are hospitalized for COVID-19 and maintain statin therapy during hospitalization have a lower mortality rate than those in whom therapy is withdrawn. In addition, statin therapy was associated with a decreased probability that patients with COVID-19 will develop AKI, ARDS, or sepsis and decreases the need for IMV.
YR 2021
FD 2021-03-29
LK https://hdl.handle.net/10668/27994
UL https://hdl.handle.net/10668/27994
LA en
DS RISalud
RD Apr 12, 2025