RT Journal Article
T1 Influence of Gender in Advanced Heart Failure Therapies and Outcome Following Transplantation.
A1 García-Cosío, María Dolores
A1 González-Vilchez, Francisco
A1 López-Vilella, Raquel
A1 Barge-Caballero, Eduardo
A1 Gómez Bueno, Manuel
A1 Martínez-Selles, Manuel
A1 María Arizón, Jose
A1 Rangel Sousa, Diego
A1 González-Costello, José
A1 Mirabet, Sonia
A1 Pérez-Villa, Félix
A1 Molina, Beatriz Díaz
A1 Rábago, Gregorio
A1 Portolés Ocampo, Ana
A1 de la Fuente Galán, Luis
A1 Garrido, Iris
A1 Delgado, Juan F
K1 advanced heart failure
K1 female
K1 gender
K1 heart transplantation
K1 outcome
K1 ventricular assist device
K1 women
AB Biological differences between males and females change the course of different diseases and affect therapeutic measures' responses. Heart failure is not an exception to these differences. Women account for a minority of patients on the waiting list for heart transplantation or other advanced heart failure therapies. The reason for this under-representation is unknown. Men have a worse cardiovascular risk profile and suffer more often from ischemic heart disease. Conversely, transplanted women are younger and more frequently have non-ischemic cardiac disorders. Women's poorer survival on the waiting list for heart transplantation has been previously described, but this trend has been corrected in recent years. The use of ventricular assist devices in women is progressively increasing, with comparable results than in men. The indication rate for a heart transplant in women (number of women on the waiting list for millions of habitants) has remained unchanged over the past 25 years. Long-term results of heart transplants are equal for both men and women. We have analyzed the data of a national registry of heart transplant patients to look for possible future directions for a more in-depth study of sex differences in this area. We have analyzed 1-year outcomes of heart transplant recipients. We found similar results in men and women and no sex-related interactions with any of the factors related to survival or differences in death causes between men and women. We should keep trying to approach sex differences in prospective studies to confirm if they deserve a different approach, which is not supported by current evidence.
SN 2297-055X
YR 2021
FD 2021-02-25
LK https://hdl.handle.net/10668/25942
UL https://hdl.handle.net/10668/25942
LA en
DS RISalud
RD Apr 4, 2025