TY  - JOUR
AU  - Carrato, A.
AU  - Benavides, M.
AU  - Massutí, B.
AU  - Ferreiro-Monteagudo, R.
AU  - García Alfonso, P.
AU  - Falcó, E.
AU  - Reboredo, M.
AU  - Cano, T.
AU  - Gallego, J.
AU  - Viéitez, J.M.
AU  - Layos, L.
AU  - Salud, A.
AU  - Polo, E.
AU  - Dotor, E.
AU  - Durán-Ogalla, G.
AU  - Rodriguez-Garrote, M.
AU  - Calvo, A.
AU  - Grande, E.
AU  - Aranda, E.
PY  - 2019
DO  - 10.1186/s12885-019-5753-7
UR  - http://hdl.handle.net/10668/3125
T2  - BMC Cancer
AB  - Background: Treatment of frail patients with advanced colorectal cancer (CRC) is controversial. This pilot phase II trial aimed to assess the efficacy and safety of regorafenib when administered in first-line to frail patients with advanced...
LA  - en
PB  - BioMed Central
KW  - Regorafenib
KW  - Colorrectal cancer
KW  - Monotherapy
KW  - First-line
KW  - Frail patients
KW  - Elderly
KW  - Neoplasias colorrectales
KW  - Anciano
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Drug Administration Routes::Administration, Oral
KW  - Medical Subject Headings::Persons::Persons::Age Groups::Adult::Aged
KW  - Medical Subject Headings::Persons::Persons::Age Groups::Adult::Aged::Aged, 80 and over
KW  - Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Asthenia
KW  - Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms
KW  - Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Pharmacological Phenomena::Dose-Response Relationship, Drug
KW  - Medical Subject Headings::Check Tags::Female
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal...
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
KW  - Medical Subject Headings::Diseases::Cardiovascular Diseases::Vascular Diseases::Hypertension
KW  - Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Phosphorus Metabolism Disorders::Hypophosphatemia
KW  - Medical Subject Headings::Check Tags::Male
KW  - Medical Subject Headings::Persons::Persons::Age Groups::Adult::Middle Aged
KW  - Medical Subject Headings::Diseases::Neoplasms::Neoplastic Processes::Neoplasm Metastasis
KW  - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons, Cyclic::Hydrocarbons, Aromatic::Benzene Derivatives::Phenylurea Compounds
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Evaluation Studies as Topic::Pilot Projects
KW  - Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Pyridines
KW  - Medical Subject Headings::Geographical Locations::Geographic Locations::Europe::Spain
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis::Treatment Outcome
KW  - Medical Subject Headings::Persons::Persons::Age Groups::Adult::Aged::Frail Elderly
TI  - First-line single-agent regorafenib in frail patients with metastatic colorectal cancer: a pilot phase II study of the Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD)
TY  - research article
ER  -