RT Journal Article
T1 Effect of Monotherapy with Darunavir/Ritonavir on Viral Load in Seminal Fluid, and Quality Parameters of Semen in HIV-1-Positive Patients.
A1 Lopez-Ruz, Miguel A
A1 Navas, Purificación
A1 Lopez-Zúñiga, Miguel A
A1 Gonzalvo, Maria Carmen
A1 Sampedro, Antonio
A1 Pasquau, Juan
A1 Hidalgo-Tenorio, Carmen
A1 Javier, Rosario
A1 Castilla, Jose A
K1 Antiretroviral Therapy, Highly Active
K1 HIV Infections
K1 Ritonavir
K1 Viral Load
AB Patients with human immunodeficiency virus type 1 (HIV-1) who receive antiretroviral therapy (ART) often achieve increased survival and improved quality of life. In this respect, monotherapy with darunavir/ritonavir (mDRV/r) can be a useful treatment strategy. This prospective study analyses the effect of mDRV/r on sperm quality and viral load in a group of 28 patients who had previously been given conventional ART and who had recorded a viral load 20 copies/ml), and that at V1, after mDRV/r treatment, this figure had fallen to 3%. The quality of seminal fluid was close to normal in 57% of patients at V0 and in 62% at V1. We conclude that, similar to ART, mDRV/r maintains HIV-1 viral load in most patients, and that there is no worsening in seminal fluid quality.
PB Public Library of Science
YR 2016
FD 2016-06-30
LK http://hdl.handle.net/10668/10292
UL http://hdl.handle.net/10668/10292
LA en
NO Lopez-Ruz MA, Navas P, López-Zúñiga MA, Gonzalvo MC, Sampedro A, Pasquau J, et al. Effect of Monotherapy with Darunavir/Ritonavir on Viral Load in Seminal Fluid, and Quality Parameters of Semen in HIV-1-Positive Patients. PLoS One. 2016 Jul 21;11(7):e0159305.
DS RISalud
RD Apr 12, 2025