%0 Journal Article
%A Lopez-Ruz, Miguel A
%A Navas, Purificación
%A Lopez-Zúñiga, Miguel A
%A Gonzalvo, Maria Carmen
%A Sampedro, Antonio
%A Pasquau, Juan
%A Hidalgo-Tenorio, Carmen
%A Javier, Rosario
%A Castilla, Jose A
%T Effect of Monotherapy with Darunavir/Ritonavir on Viral Load in Seminal Fluid, and Quality Parameters of Semen in HIV-1-Positive Patients.
%D 2016
%U http://hdl.handle.net/10668/10292
%X Patients with human immunodeficiency virus type 1 (HIV-1) who receive antiretroviral therapy (ART) often achieve increased survival and improved quality of life. In this respect, monotherapy with darunavir/ritonavir (mDRV/r) can be a useful treatment strategy. This prospective study analyses the effect of mDRV/r on sperm quality and viral load in a group of 28 patients who had previously been given conventional ART and who had recorded a viral load 20 copies/ml), and that at V1, after mDRV/r treatment, this figure had fallen to 3%. The quality of seminal fluid was close to normal in 57% of patients at V0 and in 62% at V1. We conclude that, similar to ART, mDRV/r maintains HIV-1 viral load in most patients, and that there is no worsening in seminal fluid quality.
%K Antiretroviral Therapy, Highly Active
%K HIV Infections
%K Ritonavir
%K Viral Load
%~