RT Journal Article
T1 Prognosis Relevance of Serum Cytokines in Pancreatic Cancer.
A1 Torres, Carolina
A1 Linares, Ana
A1 Alejandre, Maria José
A1 Palomino-Morales, Rogelio J
A1 Caba, Octavio
A1 Prados, Jose
A1 Aránega, Antonia
A1 Delgado, Juan R
A1 Irigoyen, Antonio
A1 Martínez-Galán, Joaquina
A1 Ortuño, Francisco M
A1 Rojas, Ignacio
A1 Perales, Sonia
K1 Marcadores biológicos
K1 Carcinoma ductal pancreático
K1 Citocinas
K1 Desoxicitidina
K1 Humanos
K1 Neoplasias pancreáticas
K1 Pronóstico
K1 Modelos de riesgos proporcionales
K1 Timidina fosforilasa
K1 Factor de crecimiento endotelial vascular derivado de glándulas endocrinas
AB The overall survival of patients with pancreatic ductal adenocarcinoma is extremely low. Although gemcitabine is the standard used chemotherapy for this disease, clinical outcomes do not reflect significant improvements, not even when combined with adjuvant treatments. There is an urgent need for prognosis markers to be found. The aim of this study was to analyze the potential value of serum cytokines to find a profile that can predict the clinical outcome in patients with pancreatic cancer and to establish a practical prognosis index that significantly predicts patients' outcomes. We have conducted an extensive analysis of serum prognosis biomarkers using an antibody array comprising 507 human cytokines. Overall survival was estimated using the Kaplan-Meier method. Univariate and multivariate Cox's proportional hazard models were used to analyze prognosis factors. To determine the extent that survival could be predicted based on this index, we used the leave-one-out cross-validation model. The multivariate model showed a better performance and it could represent a novel panel of serum cytokines that correlates to poor prognosis in pancreatic cancer. B7-1/CD80, EG-VEGF/PK1, IL-29, NRG1-beta1/HRG1-beta1, and PD-ECGF expressions portend a poor prognosis for patients with pancreatic cancer and these cytokines could represent novel therapeutic targets for this disease.
PB Hindawi Publishing Corporation
YR 2015
FD 2015
LK http://hdl.handle.net/10668/2089
UL http://hdl.handle.net/10668/2089
LA en
NO Torres C, Linares A, Alejandre MJ, Palomino-Morales RJ, Caba O, Prados J, et al. Prognosis Relevance of Serum Cytokines in Pancreatic Cancer. Biomed Res Int; 2015:518284
NO Journal Article;
DS RISalud
RD Apr 19, 2025