RT Journal Article
T1 Mitochondrial haplogroup H is related to CD4+ T cell recovery in HIV infected patients starting combination antiretroviral therapy.
A1 Medrano, Luz M
A1 Gutiérrez-Rivas, Mónica
A1 Blanco, Julià
A1 García, Marcial
A1 Jiménez-Sousa, María A
A1 Pacheco, Yolanda M
A1 Montero, Marta
A1 Iribarren, José Antonio
A1 Bernal, Enrique
A1 Martínez, Onofre Juan
A1 Benito, José M
A1 Rallón, Norma
A1 Resino, Salvador
A1 CoRIS and the HIV Biobank integrated in the Spanish AIDS Research Network Project RIS/EPICLIN 10_2015, 
K1 HIV
K1 Haplogroups
K1 Immune reconstitution
K1 Mitochondria
K1 cART
K1 mtDNA
AB The mitochondrial DNA (mtDNA) seems to influence in a large number of diseases, including HIV infection. Moreover, there is a substantial inter-individual variability in the CD4+ recovery in HIV-infected patients on combination antiretroviral therapy (cART). Our study aimed to analyze the association between mtDNA haplogroups and CD4+ recovery in HIV-infected patients on cART. This is a retrospective study of 324 naïve cART patients with CD4+  Our study included European HIV-infected patients within the N macro-cluster. The baseline values of CD4+ T-cells were similar between groups of patients stratified by the P50th of the slope of CD4+ T-cells recovery. Patients in the low CD4+ T-cells recovery group were older (p = 0.001), but this variable was included in the multivariate models. When we analyzed the frequencies of mtDNA haplogroups, no significant differences between HIV-infected individuals and healthy controls were found. We did not find any significant association between mtDNA haplogroups and the slope of CD4+ T-cells recovery by linear regression analysis. However, Patients carrying haplogroup H had a higher odds of having a better CD4+ recovery (> 9.65 CD4+ cells/mm3/month) than patients without haplogroup H (p = 0.032). The adjusted logistic regression showed that patients carrying haplogroup H had a higher likelihood of achieving a CD4+ recovery > 9.65 CD4+ cells/mm3/month [adjusted odds ratio (aOR) = 1.75 (95% CI = 1.04; 2.95); p = 0.035]. European mitochondrial haplogroup H was associated with the improved CD4+ recovery in HIV-infected patients starting cART with CD4+
YR 2018
FD 2018-12-06
LK http://hdl.handle.net/10668/13287
UL http://hdl.handle.net/10668/13287
LA en
DS RISalud
RD Apr 17, 2025