RT Journal Article
T1 Clinical, virological and phylogenetic characterization of a multiresistant HIV-1 strain outbreak in naive patients in southern Spain.
A1 Viciana, I
A1 Gonzalez-Domenech, C M
A1 Palacios, R
A1 Delgado, M
A1 Del-Arco, A
A1 Tellez, F
A1 Jarilla, F
A1 Fernandez, S
A1 Clavijo, E
A1 Santos, J
K1 Área de Gestión Sanitaria Campo de Gibraltar Oeste
K1 Área de Gestión Sanitaria Norte de Málaga
K1 Área de Gestión Sanitaria Este de Málaga-Axarquía
K1 Anti-Retroviral Agents
K1 Cluster Analysis
K1 Disease Outbreaks
K1 Disease Transmission, Infectious
K1 Drug Resistance, Multiple, Viral
AB We describe the characteristics of an HIV-1 strain with six viral reverse transcriptase mutations (D67N, T69N/D, V118I, V179D, T215S and K219Q), which we have called the Malaga strain. This strain was detected in treatment-naive patients from southern Spain. The study was undertaken at the Virgen de la Victoria Hospital, Malaga, a reference centre for the study of HIV-1 genotype resistance in Andalusia (the 'Costa del Sol'), Spain. Genotypic resistance testing was done in an automated sequencer. Phylogenetic analysis was performed using a 630 bp region of the reverse transcriptase with the mutations mentioned. Between 2007 and 2014, we detected the Malaga strain in 30 treatment-naive patients. All were MSM, seen at five hospitals on the Costa del Sol. In all cases, the HIV-1 was subtype B with viral tropism R5. Phylogenetic analysis based on the reverse transcriptase sequence showed consistent grouping (with a bootstrap value of the common node of 100%) of the isolates that shared the mutation pattern mentioned. This strain has not been detected elsewhere or in previously treated patients. All of the patients treated with first-line combination ART responded. We report a cluster of an HIV-1 strain with multiple resistance mutations that was transmitted over a period of >8 years, affecting 30 naive patients from the same geographical area. The strain was susceptible to first-line combination ART.
PB Oxford University Press
YR 2015
FD 2015-10-19
LK http://hdl.handle.net/10668/10438
UL http://hdl.handle.net/10668/10438
LA en
NO Viciana I, González-Domenech CM, Palacios R, Delgado M, Del Arco A, Tellez F, et al. Clinical, virological and phylogenetic characterization of a multiresistant HIV-1 strain outbreak in naive patients in southern Spain. J Antimicrob Chemother. 2016 Feb;71(2):357-61
NO Partially funded by the RD12/0017/0017 project (Plan Nacional R+D+I) and cofinanced by Instituto de Salud Carlos III-Subdireccio´n General de Evaluación y el Fondo Europeo de Desarrollo Regional.
DS RISalud
RD Apr 8, 2025