%0 Journal Article
%A Viciana, I
%A Gonzalez-Domenech, C M
%A Palacios, R
%A Delgado, M
%A Del-Arco, A
%A Tellez, F
%A Jarilla, F
%A Fernandez, S
%A Clavijo, E
%A Santos, J
%T Clinical, virological and phylogenetic characterization of a multiresistant HIV-1 strain outbreak in naive patients in southern Spain.
%D 2015
%U http://hdl.handle.net/10668/10438
%X We describe the characteristics of an HIV-1 strain with six viral reverse transcriptase mutations (D67N, T69N/D, V118I, V179D, T215S and K219Q), which we have called the Malaga strain. This strain was detected in treatment-naive patients from southern Spain. The study was undertaken at the Virgen de la Victoria Hospital, Malaga, a reference centre for the study of HIV-1 genotype resistance in Andalusia (the 'Costa del Sol'), Spain. Genotypic resistance testing was done in an automated sequencer. Phylogenetic analysis was performed using a 630 bp region of the reverse transcriptase with the mutations mentioned. Between 2007 and 2014, we detected the Malaga strain in 30 treatment-naive patients. All were MSM, seen at five hospitals on the Costa del Sol. In all cases, the HIV-1 was subtype B with viral tropism R5. Phylogenetic analysis based on the reverse transcriptase sequence showed consistent grouping (with a bootstrap value of the common node of 100%) of the isolates that shared the mutation pattern mentioned. This strain has not been detected elsewhere or in previously treated patients. All of the patients treated with first-line combination ART responded. We report a cluster of an HIV-1 strain with multiple resistance mutations that was transmitted over a period of >8 years, affecting 30 naive patients from the same geographical area. The strain was susceptible to first-line combination ART.
%K Área de Gestión Sanitaria Campo de Gibraltar Oeste
%K Área de Gestión Sanitaria Norte de Málaga
%K Área de Gestión Sanitaria Este de Málaga-Axarquía
%K Anti-Retroviral Agents
%K Cluster Analysis
%K Disease Outbreaks
%K Disease Transmission, Infectious
%K Drug Resistance, Multiple, Viral
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