RT Journal Article
T1 The acidophilic microalgaCoccomyxa onubensisand atorvastatin equally improve antihyperglycemic and antihyperlipidemic protective effects on rats fed on high-fat diets
A1 Navarro, Francisco
A1 Toimil, Alberto
A1 Ramirez, Sara
A1 Montero, Yina
A1 Luis Fuentes, Juan
A1 Perona, Javier S.
A1 Angel Castano, Miguel
A1 Pasaro, Rosario
A1 Vega, Jose M.
A1 Vilchez, Carlos
K1 Atorvastatin
K1 Coccomyxa onubensis
K1 Chlorophyceae
K1 Polyunsaturated fatty acids
K1 Hypercholesterolemia
K1 Hyperglycemia
K1 Rat metabolic syndrome
K1 Lipid-metabolism
K1 Microalgae
K1 Algae
K1 Acids
K1 Food
K1 Cholesterol
K1 Supplements
K1 Cognition
K1 Plasma
K1 Brain
AB Biomass of the acidophilic green algaCoccomyxa onubensismay be used as a food source for animals without collateral toxic effects, as diet supplemented the microalga has significant hypoglycemic and hypocholesterolemic effects on healthy animals. Rats were fed for 108 days with a high-fat diet, and at the end of the experiment, they were overweight and had significantly increased serum levels of glucose (2.0-fold), total cholesterol (1.6-fold), and low-density lipoprotein (LDL)-cholesterol (7.7-fold). The supplement ofC. onubensispowder (6.25% w/w dry weight) in the high-fat diet significantly protected the rats against cardiovascular risks by reducing the serum levels of glucose (38.47%), total cholesterol (22.65%), and LDL-cholesterol (26.70%). The protective effects of the microalga were comparable with that of 10 mg/kg body weight per day of atorvastatin. The high-fat diet decreased both omega-3 eicosapentaenoic and docosahexaenoic acids in the brain tissue of rats; however,C. onubensispowder could not restrict these changes. Simultaneously, the high-fat diet increased the levels of both palmitic and arachidonic (omega-6) acids in the telencephalon tissue of rats; this was prevented when microalga biomass was used in the diet of rats.
PB Springer
SN 0921-8971
YR 2020
FD 2020-10-06
LK http://hdl.handle.net/10668/18642
UL http://hdl.handle.net/10668/18642
LA en
DS RISalud
RD Apr 17, 2025