%0 Journal Article
%A Navarro, Francisco
%A Toimil, Alberto
%A Ramirez, Sara
%A Montero, Yina
%A Luis Fuentes, Juan
%A Perona, Javier S.
%A Angel Castano, Miguel
%A Pasaro, Rosario
%A Vega, Jose M.
%A Vilchez, Carlos
%T The acidophilic microalgaCoccomyxa onubensisand atorvastatin equally improve antihyperglycemic and antihyperlipidemic protective effects on rats fed on high-fat diets
%D 2020
%@ 0921-8971
%U http://hdl.handle.net/10668/18642
%X Biomass of the acidophilic green algaCoccomyxa onubensismay be used as a food source for animals without collateral toxic effects, as diet supplemented the microalga has significant hypoglycemic and hypocholesterolemic effects on healthy animals. Rats were fed for 108 days with a high-fat diet, and at the end of the experiment, they were overweight and had significantly increased serum levels of glucose (2.0-fold), total cholesterol (1.6-fold), and low-density lipoprotein (LDL)-cholesterol (7.7-fold). The supplement ofC. onubensispowder (6.25% w/w dry weight) in the high-fat diet significantly protected the rats against cardiovascular risks by reducing the serum levels of glucose (38.47%), total cholesterol (22.65%), and LDL-cholesterol (26.70%). The protective effects of the microalga were comparable with that of 10 mg/kg body weight per day of atorvastatin. The high-fat diet decreased both omega-3 eicosapentaenoic and docosahexaenoic acids in the brain tissue of rats; however,C. onubensispowder could not restrict these changes. Simultaneously, the high-fat diet increased the levels of both palmitic and arachidonic (omega-6) acids in the telencephalon tissue of rats; this was prevented when microalga biomass was used in the diet of rats.
%K Atorvastatin
%K Coccomyxa onubensis
%K Chlorophyceae
%K Polyunsaturated fatty acids
%K Hypercholesterolemia
%K Hyperglycemia
%K Rat metabolic syndrome
%K Lipid-metabolism
%K Microalgae
%K Algae
%K Acids
%K Food
%K Cholesterol
%K Supplements
%K Cognition
%K Plasma
%K Brain
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