RT Journal Article
T1 Regulation of Mitotic Exit by Cell Cycle Checkpoints: Lessons From Saccharomyces cerevisiae
A1 Matellán, Laura
A1 Monje-Casas, Fernando
K1 Mitosis
K1 Checkpoint
K1 DNA damage
K1 Chromosome segregation
K1 Aneuploidy
K1 Puntos de control del ciclo celular
K1 Daño del ADN
K1 Segregación cromosómica
K1 Aneuploidia
AB In order to preserve genome integrity and their ploidy, cells must ensure that the duplicated genome has been faithfully replicated and evenly distributed before they complete their division by mitosis. To this end, cells have developed highly elaborated checkpoints that halt mitotic progression when problems in DNA integrity or chromosome segregation arise, providing them with time to fix these issues before advancing further into the cell cycle. Remarkably, exit from mitosis constitutes a key cell cycle transition that is targeted by the main mitotic checkpoints, despite these surveillance mechanisms being activated by specific intracellular signals and acting at different stages of cell division. Focusing primarily on research carried out using Saccharomyces cerevisiae as a model organism, the aim of this review is to provide a general overview of the molecular mechanisms by which the major cell cycle checkpoints control mitotic exit and to highlight the importance of the proper regulation of this process for the maintenance of genome stability during the distribution of the duplicated chromosomes between the dividing cells.
PB MDPI
YR 2020
FD 2020-02-12
LK http://hdl.handle.net/10668/3645
UL http://hdl.handle.net/10668/3645
LA en
NO Matellán L, Monje-Casas F. Regulation of Mitotic Exit by Cell Cycle Checkpoints: Lessons From Saccharomyces cerevisiae. Genes. 2020 Feb 12;11(2):195
DS RISalud
RD Apr 15, 2025