%0 Journal Article %A Muñoz-Gómez, Ana %A Fernández-Cruz, Ana %A Lavilla-Olleros, Cristina %A Giner-Galvañ, Vicente %A Ausín-García, Cristina %A Wikman, Philip %A Bendala-Estrada, Alejandro D %A Vargas, Juan A %A Rubio-Rivas, Manuel %A Laureiro, Jaime %A Fernández-Bermúdez, Daniel %A Buonaiuto, Verónica A %A Arenas de Larriva, Antonio P %A Pascual-Pérez, María de Los Reyes %A Alcalá-Pedrajas, José N %A Labirua-Iturburu Ruiz, Ane %A Hernández-Milián, Almudena %A Gómez Del Mazo, Marta %A Antequera, Beatriz %A Mella-Pérez, Carmen %A Navas-Alcántara, María de la Sierra %A Soto-Delgado, Juan F %A Gámez-Mancera, Rosa M %A Sardiña-González, Cristina %A Meijide-Míguez, Héctor %A Ramos-Rincón, José M %A Gómez-Huelgas, Ricardo %A On Behalf Of The Semi-Covid-Network, %T Real-Life Impact of Glucocorticoid Treatment in COVID-19 Mortality: A Multicenter Retrospective Study. %D 2021 %@ 2077-0383 %U https://hdl.handle.net/10668/25893 %X We aimed to determine the impact of steroid use in COVID-19 in-hospital mortality, in a retrospective cohort study of the SEMICOVID19 database of admitted patients with SARS-CoV-2 laboratory-confirmed pneumonia from 131 Spanish hospitals. Patients treated with corticosteroids were compared to patients not treated with corticosteroids; and adjusted using a propensity-score for steroid treatment. From March-July 2020, 5.262 (35.26%) were treated with corticosteroids and 9.659 (64.73%) were not. In-hospital mortality overall was 20.50%; it was higher in patients treated with corticosteroids than in controls (28.5% versus 16.2%, OR 2.068 [95% confidence interval; 1.908 to 2.242]; p = 0.0001); however, when adjusting by occurrence of ARDS, mortality was significantly lower in the steroid group (43.4% versus 57.6%; OR 0.564 [95% confidence interval; 0.503 to 0.633]; p = 0.0001). Moreover, the greater the respiratory failure, the greater the impact on mortality of the steroid treatment. When adjusting these results including the propensity score as a covariate, in-hospital mortality remained significantly lower in the steroid group (OR 0.774 [0.660 to 0.907], p = 0.002). Steroid treatment reduced mortality by 24% relative to no steroid treatment (RRR 0.24). These results support the use of glucocorticoids in COVID-19 in this subgroup of patients. %K COVID-19 %K SARS-CoV-2 %K corticosteroids %K mortality %~