RT Journal Article
T1 Brain region volumes and their relationship with disability progression and cognitive function in primary progressive multiple sclerosis.
A1 Perez-Miralles, Francisco Carlos
A1 Prefasi, Daniel
A1 Garcia-Merino, Antonio
A1 Ara, Jose Ramon
A1 Izquierdo, Guillermo
A1 Meca-Lallana, Virginia
A1 Gascon-Gimenez, Francisco
A1 Martinez-Gines, Maria Luisa
A1 Ramio-Torrenta, Lluis
A1 Costa-Frossard, Lucienne
A1 Fernandez, Oscar
A1 Moreno-Garcia, Sara
A1 Maurino, Jorge
A1 Carreres-Polo, Joan
A1 Casanova, Bonaventura
K1 Brain volume
K1 Cognitive function
K1 Disability progression
K1 Magnetic resonance imaging
K1 Primary progressive multiple sclerosis
AB Evidence on regional changes resulting from neurodegenerative processes underlying primary progressive multiple sclerosis (PPMS) is still limited. We assessed brain region volumes and their relationship with disability progression and cognitive function in PPMS patients. This was an MRI analysis of 43 patients from the prospective Understanding Primary Progressive Multiple Sclerosis (UPPMS) cohort study. MRI scans were performed within 3 months before enrollment and at month 12. Gray matter volume of declive and white matter volumes adjacent to left straight gyrus, right calcarine sulcus, and right inferior occipital gyrus significantly decreased from baseline to month 12. Baseline white matter volumes adjacent to right amygdala and left cuneus significantly differed between patients with and without disability progression, as well as baseline gray matter volumes of left cuneus, right parahippocampal gyrus, right insula, left superior frontal gyrus, declive, right inferior temporal gyrus, right superior temporal gyrus (pole), and right calcarine sulcus. Baseline gray matter volumes of right cuneus and right superior temporal gyrus positively correlated with 12-month Selective Reminding Test and Word List Generation performance, respectively. Gray matter changes in right superior semilunar lobe and white matter adjacent to left declive and right cerebellar tonsil also positively correlated with Word List Generation scores, while white matter change in left inferior semilunar lobe positively correlated with Symbol Digit Modalities Test performance after 12 months. White and gray matter volumes of specific brain regions could predict disability progression and cognitive performance of PPMS patients after one year.
PB Wiley Periodicals
YR 2020
FD 2020-12-04
LK http://hdl.handle.net/10668/17030
UL http://hdl.handle.net/10668/17030
LA en
NO Pérez-Miralles FC, Prefasi D, García-Merino A, Ara JR, Izquierdo G, Meca-Lallana V, et al. Brain region volumes and their relationship with disability progression and cognitive function in primary progressive multiple sclerosis. Brain Behav. 2021 Apr;11(4):e02044
DS RISalud
RD Apr 11, 2025