RT Journal Article
T1 Regulation of mitochondrial function and endoplasmic reticulum stress by nitric oxide in pluripotent stem cells.
A1 Caballano-Infantes, Estefania
A1 Terron-Bautista, José
A1 Beltrán-Povea, Amparo
A1 Cahuana, Gladys M
A1 Soria, Bernat
A1 Nabil, Hajji
A1 Bedoya, Francisco J
A1 Tejedo, Juan R
K1 Cell differentiation
K1 Endoplasmic reticulum stress
K1 Mitochondrial biogenesis
K1 Mitochondrial function
K1 Nitric oxide
K1 Pluripotency
AB Mitochondrial dysfunction and endoplasmic reticulum stress (ERS) are global processes that are interrelated and regulated by several stress factors. Nitric oxide (NO) is a multifunctional biomolecule with many varieties of physiological and pathological functions, such as the regulation of cytochrome c inhibition and activation of the immune response, ERS and DNA damage; these actions are dose-dependent. It has been reported that in embryonic stem cells, NO has a dual role, controlling differentiation, survival and pluripotency, but the molecular mechanisms by which it modulates these functions are not yet known. Low levels of NO maintain pluripotency and induce mitochondrial biogenesis. It is well established that NO disrupts the mitochondrial respiratory chain and causes changes in mitochondrial Ca2+ flux that induce ERS. Thus, at high concentrations, NO becomes a potential differentiation agent due to the relationship between ERS and the unfolded protein response in many differentiated cell lines. Nevertheless, many studies have demonstrated the need for physiological levels of NO for a proper ERS response. In this review, we stress the importance of the relationships between NO levels, ERS and mitochondrial dysfunction that control stem cell fate as a new approach to possible cell therapy strategies.
SN 1948-0210
YR 2017
FD 2017
LK http://hdl.handle.net/10668/10959
UL http://hdl.handle.net/10668/10959
LA en
DS RISalud
RD Apr 11, 2025