RT Journal Article
T1 Exposure to a Highly Caloric Palatable Diet During Pregestational and Gestational Periods Affects Hypothalamic and Hippocampal Endocannabinoid Levels at Birth and Induces Adiposity and Anxiety-Like Behaviors in Male Rat Offspring.
A1 Ramírez-López, María Teresa
A1 Vázquez, Mariam
A1 Bindila, Laura
A1 Lomazzo, Ermelinda
A1 Hofmann, Clementine
A1 Blanco, Rosario Noemí
A1 Alén, Francisco
A1 Antón, María
A1 Decara, Juan
A1 Ouro, Daniel
A1 Orio, Laura
A1 Suarez, Juan
A1 Lutz, Beat
A1 Rodríguez de Fonseca, Fernando
A1 Gómez de Heras, Raquel
K1 Maternal diet
K1 Endocannabinoids
K1 Adipogenesis
K1 Anxiety
K1 Development
K1 Hypothalamus
K1 Hippocampus
K1 Adiposidad
K1 Ansiedad
K1 Ácido araquidónico
K1 Cacao
K1 Cannabinoides
K1 Dieta
K1 Emociones
K1 Endocannabinoides
K1 Etanolaminas
K1 Preferencias alimentarias
K1 Glicéridos
K1 Hipocampo
K1 Lactancia
K1 Masculino
K1 Exposición materna
K1 Madres
K1 Ácidos oléicos
K1 Ácidos palmíticos
K1 Fenotipo
K1 Alcamidas poliinsaturadas
K1 Ratas
K1 Destete
AB Exposure to unbalanced diets during pre-gestational and gestational periods may result in long-term alterations in metabolism and behavior. The contribution of the endocannabinoid system to these long-term adaptive responses is unknown. In the present study, we investigated the impact of female rat exposure to a hypercaloric-hypoproteic palatable diet during pre-gestational, gestational and lactational periods on the development of male offspring. In addition, the hypothalamic and hippocampal endocannabinoid contents at birth and the behavioral performance in adulthood were investigated. Exposure to a palatable diet resulted in low weight offspring who exhibited low hypothalamic contents of arachidonic acid and the two major endocannabinoids (anandamide and 2-arachidonoylglycerol) at birth. Palmitoylethanolamide, but not oleoylethanolamide, also decreased. Additionally, pups from palatable diet-fed dams displayed lower levels of anandamide and palmitoylethanolamide in the hippocampus. The low-weight male offspring, born from palatable diet exposed mothers, gained less weight during lactation and although they recovered weight during the post-weaning period, they developed abdominal adiposity in adulthood. These animals exhibited anxiety-like behavior in the elevated plus-maze and open field test and a low preference for a chocolate diet in a food preference test, indicating that maternal exposure to a hypercaloric diet induces long-term behavioral alterations in male offspring. These results suggest that maternal diet alterations in the function of the endogenous cannabinoid system can mediate the observed phenotype of the offspring, since both hypothalamic and hippocampal endocannabinoids regulate feeding, metabolic adaptions to caloric diets, learning, memory, and emotions.
PB Frontiers Media
YR 2016
FD 2016-01-06
LK http://hdl.handle.net/10668/2502
UL http://hdl.handle.net/10668/2502
LA en
NO Ramírez-López MT, Vázquez M, Bindila L, Lomazzo E, Hofmann C, Blanco RN, et al. Exposure to a Highly Caloric Palatable Diet During Pregestational and Gestational Periods Affects Hypothalamic and Hippocampal Endocannabinoid Levels at Birth and Induces Adiposity and Anxiety-Like Behaviors in Male Rat Offspring. Front Behav Neurosci. 2016; 9:339
NO Journal Article;
DS RISalud
RD Apr 18, 2025