RT Journal Article
T1 MiRNAs and Muscle Regeneration: Therapeutic Targets in Duchenne Muscular Dystrophy.
A1 Aránega, Amelia Eva
A1 Lozano-Velasco, Estefanía
A1 Rodriguez-Outeiriño, Lara
A1 Ramírez de Acuña, Felicitas
A1 Franco, Diego
A1 Hernández-Torres, Francisco
K1 microRNA
K1 muscle regeneration
K1 muscular dystrophies
K1 myogenesis
K1 satellite cell
AB microRNAs (miRNAs) are small non-coding RNAs required for the post-transcriptional control of gene expression. MicroRNAs play a critical role in modulating muscle regeneration and stem cell behavior. Muscle regeneration is affected in muscular dystrophies, and a critical point for the development of effective strategies for treating muscle disorders is optimizing approaches to target muscle stem cells in order to increase the ability to regenerate lost tissue. Within this framework, miRNAs are emerging as implicated in muscle stem cell response in neuromuscular disorders and new methodologies to regulate the expression of key microRNAs are coming up. In this review, we summarize recent advances highlighting the potential of miRNAs to be used in conjunction with gene replacement therapies, in order to improve muscle regeneration in the context of Duchenne Muscular Dystrophy (DMD).
YR 2021
FD 2021-04-19
LK http://hdl.handle.net/10668/17696
UL http://hdl.handle.net/10668/17696
LA en
DS RISalud
RD Apr 7, 2025