RT Journal Article
T1 Effect of mistimed eating patterns on breast and prostate cancer risk (MCC-Spain Study).
A1 Kogevinas, Manolis
A1 Espinosa, Ana
A1 Castelló, Adela
A1 Gómez-Acebo, Inés
A1 Guevara, Marcela
A1 Martin, Vicente
A1 Amiano, Pilar
A1 Alguacil, Juan
A1 Peiro, Rosana
A1 Moreno, Victor
A1 Costas, Laura
A1 Fernández-Tardón, Guillermo
A1 Jimenez, Jose Juan
A1 Marcos-Gragera, Rafael
A1 Perez-Gomez, Beatriz
A1 Llorca, Javier
A1 Moreno-Iribas, Conchi
A1 Fernández-Villa, Tania
A1 Oribe, Madalen
A1 Aragones, Nuria
A1 Papantoniou, Kyriaki
A1 Pollán, Marina
A1 Castano-Vinyals, Gemma
A1 Romaguera, Dora
K1 breast cancer
K1 circadian disruption
K1 diet
K1 prostate cancer
AB Modern life involves mistimed sleeping and eating patterns that in experimental studies are associated with adverse health effects. We assessed whether timing of meals is associated with breast and prostate cancer risk taking into account lifestyle and chronotype, a characteristic correlating with preference for morning or evening activity. We conducted a population-based case-control study in Spain, 2008-2013. In this analysis we included 621 cases of prostate and 1,205 of breast cancer and 872 male and 1,321 female population controls who had never worked night shift. Subjects were interviewed on timing of meals, sleep and chronotype and completed a Food Frequency Questionaire. Adherence to the World Cancer Research Fund/American Institute of Cancer Research recommendations for cancer prevention was examined. Compared with subjects sleeping immediately after supper, those sleeping two or more hours after supper had a 20% reduction in cancer risk for breast and prostate cancer combined (adjusted Odds Ratio [OR] = 0.80, 95%CI 0.67-0.96) and in each cancer individually (prostate cancer OR = 0.74, 0.55-0.99; breast cancer OR = 0.84, 0.67-1.06). A similar protection was observed in subjects having supper before 9 pm compared with supper after 10 pm. The effect of longer supper-sleep interval was more pronounced among subjects adhering to cancer prevention recommendations (OR both cancers= 0.65, 0.44-0.97) and in morning types (OR both cancers = 0.66, 0.49-0.90). Adherence to diurnal eating patterns and specifically a long interval between last meal and sleep are associated with a lower cancer risk, stressing the importance of evaluating timing in studies on diet and cancer.
YR 2018
FD 2018-07-17
LK http://hdl.handle.net/10668/12719
UL http://hdl.handle.net/10668/12719
LA en
DS RISalud
RD Apr 8, 2025