RT Journal Article
T1 Clinicopathologic Features and Prognostic Impact of Lymph Node Involvement in Patients With Breast Implant-associated Anaplastic Large Cell Lymphoma.
A1 Ferrufino-Schmidt, Maria C
A1 Medeiros, L Jeffrey
A1 Liu, Hui
A1 Clemens, Mark W
A1 Hunt, Kelly K
A1 Laurent, Camille
A1 Lofts, Julian
A1 Amin, Mitual B
A1 Ming Chai, Siaw
A1 Morine, Angela
A1 Di Napoli, Arianna
A1 Dogan, Ahmet
A1 Parkash, Vinita
A1 Bhagat, Govind
A1 Tritz, Denise
A1 Quesada, Andres E
A1 Pina-Oviedo, Sergio
A1 Hu, Qinlong
A1 Garcia-Gomez, Francisco J
A1 Jose Borrero, Juan
A1 Horna, Pedro
A1 Thakral, Beenu
A1 Narbaitz, Marina
A1 Hughes, R Condon
A1 Yang, Li-Jun
A1 Fromm, Jonathan R
A1 Wu, David
A1 Zhang, Da
A1 Sohani, Aliyah R
A1 Hunt, John
A1 Vadlamani, Indira U
A1 Morgan, Elizabeth A
A1 Ferry, Judith A
A1 Szigeti, Reka
A1 C Tardio, Juan
A1 Granados, Rosario
A1 Dertinger, Susanne
A1 Offner, Felix A
A1 Pircher, Andreas
A1 Hosry, Jeff
A1 Young, Ken H
A1 Miranda, Roberto N
AB Breast implant-associated anaplastic large cell lymphoma (BI-ALCL) is a rare T-cell lymphoma that arises around breast implants. Most patients manifest with periprosthetic effusion, whereas a subset of patients develops a tumor mass or lymph node involvement (LNI). The aim of this study is to describe the pathologic features of lymph nodes from patients with BI-ALCL and assess the prognostic impact of LNI. Clinical findings and histopathologic features of lymph nodes were assessed in 70 patients with BI-ALCL. LNI was defined by the histologic demonstration of ALCL in lymph nodes. Fourteen (20%) patients with BI-ALCL had LNI, all lymph nodes involved were regional, the most frequent were axillary (93%). The pattern of involvement was sinusoidal in 13 (92.9%) cases, often associated with perifollicular, interfollicular, and diffuse patterns. Two cases had Hodgkin-like patterns. The 5-year overall survival was 75% for patients with LNI and 97.9% for patients without LNI at presentation (P=0.003). Six of 49 (12.2%) of patients with tumor confined by the capsule had LNI, compared with LNI in 8/21 (38%) patients with tumor beyond the capsule. Most patients with LNI achieved complete remission after various therapeutic approaches. Two of 14 (14.3%) patients with LNI died of disease compared with 0/56 (0%) patients without LNI. Twenty percent of patients with BI-ALCL had LNI by lymphoma, most often in a sinusoidal pattern. We conclude that BI-ALCL beyond capsule is associated with a higher risk of LNI. Involvement of lymph nodes was associated with decreased overall survival. Misdiagnosis as Hodgkin lymphoma is a pitfall.
YR 2018
FD 2018
LK http://hdl.handle.net/10668/11865
UL http://hdl.handle.net/10668/11865
LA en
DS RISalud
RD Apr 5, 2025