%0 Journal Article
%A Ferrufino-Schmidt, Maria C
%A Medeiros, L Jeffrey
%A Liu, Hui
%A Clemens, Mark W
%A Hunt, Kelly K
%A Laurent, Camille
%A Lofts, Julian
%A Amin, Mitual B
%A Ming Chai, Siaw
%A Morine, Angela
%A Di Napoli, Arianna
%A Dogan, Ahmet
%A Parkash, Vinita
%A Bhagat, Govind
%A Tritz, Denise
%A Quesada, Andres E
%A Pina-Oviedo, Sergio
%A Hu, Qinlong
%A Garcia-Gomez, Francisco J
%A Jose Borrero, Juan
%A Horna, Pedro
%A Thakral, Beenu
%A Narbaitz, Marina
%A Hughes, R Condon
%A Yang, Li-Jun
%A Fromm, Jonathan R
%A Wu, David
%A Zhang, Da
%A Sohani, Aliyah R
%A Hunt, John
%A Vadlamani, Indira U
%A Morgan, Elizabeth A
%A Ferry, Judith A
%A Szigeti, Reka
%A C Tardio, Juan
%A Granados, Rosario
%A Dertinger, Susanne
%A Offner, Felix A
%A Pircher, Andreas
%A Hosry, Jeff
%A Young, Ken H
%A Miranda, Roberto N
%T Clinicopathologic Features and Prognostic Impact of Lymph Node Involvement in Patients With Breast Implant-associated Anaplastic Large Cell Lymphoma.
%D 2018
%U http://hdl.handle.net/10668/11865
%X Breast implant-associated anaplastic large cell lymphoma (BI-ALCL) is a rare T-cell lymphoma that arises around breast implants. Most patients manifest with periprosthetic effusion, whereas a subset of patients develops a tumor mass or lymph node involvement (LNI). The aim of this study is to describe the pathologic features of lymph nodes from patients with BI-ALCL and assess the prognostic impact of LNI. Clinical findings and histopathologic features of lymph nodes were assessed in 70 patients with BI-ALCL. LNI was defined by the histologic demonstration of ALCL in lymph nodes. Fourteen (20%) patients with BI-ALCL had LNI, all lymph nodes involved were regional, the most frequent were axillary (93%). The pattern of involvement was sinusoidal in 13 (92.9%) cases, often associated with perifollicular, interfollicular, and diffuse patterns. Two cases had Hodgkin-like patterns. The 5-year overall survival was 75% for patients with LNI and 97.9% for patients without LNI at presentation (P=0.003). Six of 49 (12.2%) of patients with tumor confined by the capsule had LNI, compared with LNI in 8/21 (38%) patients with tumor beyond the capsule. Most patients with LNI achieved complete remission after various therapeutic approaches. Two of 14 (14.3%) patients with LNI died of disease compared with 0/56 (0%) patients without LNI. Twenty percent of patients with BI-ALCL had LNI by lymphoma, most often in a sinusoidal pattern. We conclude that BI-ALCL beyond capsule is associated with a higher risk of LNI. Involvement of lymph nodes was associated with decreased overall survival. Misdiagnosis as Hodgkin lymphoma is a pitfall.
%~