RT Journal Article
T1 Do high MICs predict the outcome in invasive fusariosis?
A1 Nucci, Marcio
A1 Jenks, Jeffrey
A1 Thompson, George R
A1 Hoenigl, Martin
A1 Dos Santos, Marielle Camargo
A1 Forghieri, Fabio
A1 Rico, Juan Carlos
A1 Bonuomo, Valentina
A1 López-Soria, Leyre
A1 Lass-Flörl, Cornelia
A1 Candoni, Anna
A1 Garcia-Vidal, Carolina
A1 Cattaneo, Chiara
A1 Buil, Jochem
A1 Rabagliati, Ricardo
A1 Roiz, Maria Pia
A1 Gudiol, Carlota
A1 Fracchiolla, Nicola
A1 Campos-Herrero, Maria Isolina
A1 Delia, Mario
A1 Farina, Francesca
A1 Fortun, Jesus
A1 Nadali, Gianpaolo
A1 Sastre, Enric
A1 Colombo, Arnaldo L
A1 Pérez Nadales, Elena
A1 Alastruey-Izquierdo, Ana
A1 Pagano, Livio
AB Invasive fusariosis (IF) affects mostly severely immunocompromised hosts and is associated with poor outcome. Since Fusarium species exhibit high MICs for most antifungal agents, this could explain the poor prognosis. However, a clear-cut correlation between MIC and outcome has not been established. To evaluate the correlation between MIC and outcome (6 week death rate) in patients with IF. We performed a multicentre retrospective study of patients with IF who received treatment and had MIC levels determined by EUCAST or CLSI for the drug(s) used during treatment. We compared the MIC50 and MIC distribution among survivors and patients who died within 6 weeks from the diagnosis of IF. Among 88 patients with IF, 74 had haematological diseases. Primary treatment was monotherapy in 52 patients (voriconazole in 27) and combination therapy in 36 patients (liposomal amphotericin B + voriconazole in 23). The MIC50 and range for the five most frequent agents tested were: voriconazole 8 mg/L (range 0.5-64), amphotericin B 2 mg/L (range 0.25-64), posaconazole 16 mg/L (range 0.5-64), itraconazole 32 mg/L (range 4-64), and isavuconazole 32 mg/L (range 8-64). There was no difference in MIC50 and MIC distribution among survivors and patients who died. By contrast, persistent neutropenia and receipt of corticosteroids were strong predictors of 6 week mortality. Our study did not show any correlation between MIC and mortality at 6 weeks in patients with IF.
YR 2021
FD 2021
LK http://hdl.handle.net/10668/16801
UL http://hdl.handle.net/10668/16801
LA en
DS RISalud
RD Apr 9, 2025