TY  - JOUR
AU  - Lázaro-Gorines, Rodrigo
AU  - López-Rodríguez, Juan Carlos
AU  - Benedé, Sara
AU  - González, Miguel
AU  - Mayorga, Cristobalina
AU  - Vogel, Lothar
AU  - Martínez-Del-Pozo, Álvaro
AU  - Lacadena, Javier
AU  - Villalba, Mayte
PY  - 2020
DO  - 10.1038/s41598-020-69166-w
UR  - http://hdl.handle.net/10668/4059
T2  - Scientific Reports
AB  - Immunotoxins appear as promising therapeutic molecules, alternative to allergen-specific-immunotherapy. In this work, we achieved the development of a protein chimera able to promote specific cell death on effector cells involved in the allergic...
LA  - en
PB  - Springer Nature
KW  - Allergy
KW  - Der p 1
KW  - Immunotoxins
KW  - Basophils
KW  - Cell death
KW  - Pyroglyphidae
KW  - Hipersensibilidad
KW  - Inmunotoxinas
KW  - Basófilos
KW  - Muerte celular
KW  - Medical Subject Headings::Chemicals and Drugs::Biological Factors::Antigens::Allergens
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals
KW  - Medical Subject Headings::Chemicals and Drugs::Biological Factors::Antigens::Antigens, Dermatophagoides
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Arthropod Proteins
KW  - Medical Subject Headings::Anatomy::Cells::Blood Cells::Leukocytes::Granulocytes::Basophils
KW  - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Exocytosis::Cell Degranulation
KW  - Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line
KW  - Medical Subject Headings::Anatomy::Cells::Cells, Cultured
KW  - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Peptide Hydrolases::Cysteine Proteases::Cysteine Endopeptidases
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Invertebrates::Arthropods::Arachnida::Acari::Mites::Pyroglyphidae::Dermatophagoides pteronyssinus
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy::Immunosuppression::Desensitization, Immunologic
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
KW  - Medical Subject Headings::Diseases::Immune System Diseases::Hypersensitivity
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Immunoglobulin Isotypes::Immunoglobulin E
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Immunoconjugates::Immunotoxins
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Recombinant Proteins
KW  - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Exocytosis::Cell Degranulation
KW  - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death
TI  - Der p 1-based immunotoxin as potential tool for the treatment of dust mite respiratory allergy
TY  - research article
ER  -