RT Journal Article
T1 8-weeks training program attenuates mitochondrial oxidative stress in the liver of emotionally stressed rats
A1 Rosety-Rodriguez, M
A1 Ordonez, F J
A1 Rosety, I
A1 Frias, L
A1 Rosety, M A
A1 Rosety, J M
A1 Rosety, M
K1 Exercise
K1 Mitochondria
K1 Oxidative Stress
K1 Emotional stress
K1 Ejercicio
K1 Mitocondrias
K1 Estrés oxidativo
K1 Estrés emocional
K1 Conducta animal
K1 Hígado
K1 Condicionamiento físico animal
K1 Ratas
K1 Ratas Wistar
K1 Oxigeno
AB In recent years it has been shown that emotional stress induced by immobilization may change the balance between pro-oxidant and antioxidant factors inducing oxidative damage. On the other hand, contradictory views exist concerning the role of physical activity on redox metabolism. Consequently, the present work was designed to assess the influence of an 8-week moderate swimming training program in emotionally stressed rats. Sixty 1-month-old male albino Wistar rats weighing 125-135 g were used in this experimental study. They were divided into three groups, as Control (lot A; n=20), Stressed (lot B; n=20) and Stressed & Exercised (lot C; n=20). Rats were stressed by placing the animals in a 25 x 7 cm plastic bottle 1 h/day, 5 days a week for 8 weeks. Protein carbonyl content values in liver homogenates were significantly increased in stressed animals (0.58+/-0.02 vs 0.86+/-0.03; p=0.018) which clearly indicated that emotional stress was associated with oxidative stress. Ultrastructural alterations, predominantly mitochondrial swelling and the decrease of cristae number observed by electron microscopy represented direct evidence of membrane injury. The most striking feature of our study was that we also found differences between stressed rats and stressed rats that performed our 8 week training program. Consequently our results highlight the potential benefit of a moderate training program to reduce oxidative damage induced by emotional stress since it attenuated protein oxidation and mitochondrial alterations.
PB Universidad de Murcia
SN 0213-3911
YR 2006
FD 2006-11
LK http://hdl.handle.net/10668/613
UL http://hdl.handle.net/10668/613
LA en
NO Rosety-Rodriguez M, Ordonez FJ, Rosety I, Frias L, Rosety MA, Rosety JM, et al. 8-weeks training program attenuates mitochondrial oxidative stress in the liver of emotionally stressed rats. Histol. Histopathol.. 2006 Nov; 21(11):1167-70
NO Journal Article;
DS RISalud
RD Apr 5, 2025