RT Journal Article
T1 Gemcitabine-Loaded Magnetically Responsive Poly(ε-caprolactone) Nanoparticles against Breast Cancer.
A1 García-García, Gracia
A1 Fernández-Álvarez, Fátima
A1 Cabeza, Laura
A1 Delgado, Ángel V
A1 Melguizo, Consolación
A1 Prados, José C
A1 Arias, José L
K1 Gemcitabine
K1 breast cancer
K1 core/shell
K1 drug loading
K1 magnetic drug delivery
K1 magnetite
K1 pH-responsive drug release
K1 poly(ε-caprolactone)
K1 polymer-coated nanoparticle
AB A reproducible and efficient interfacial polymer disposition method has been used to formulate magnetite/poly(ε-caprolactone) (core/shell) nanoparticles (average size ≈ 125 nm, production performance ≈ 90%). To demonstrate that the iron oxide nuclei were satisfactorily embedded within the polymeric solid matrix, a complete analysis of these nanocomposites by, e.g., electron microscopy visualizations, energy dispersive X-ray spectroscopy, Fourier-transform infrared spectroscopy, electrophoresis, and contact angle goniometry was conducted. The magnetic responsive behaviour of these nanoparticles was quantitatively characterized by the hysteresis cycle and qualitatively investigated by visualization of the colloid under exposure to a 0.4 T magnet. Gemcitabine entrapment into the polymeric shell reported adequate drug loading values (≈11%), and a biphasic and pH-responsive drug release profile (≈ four-fold faster Gemcitabine release at pH 5.0 compared to pH 7.4). Cytotoxicity studies in MCF-7 human breast cancer cells proved that the half maximal inhibitory concentration of Gem-loaded nanocomposites was ≈ two-fold less than that of the free drug. Therefore, these core/shell nanoparticles could have great possibilities as a magnetically targeted Gemcitabine delivery system for breast cancer treatment.
YR 2020
FD 2020-11-25
LK https://hdl.handle.net/10668/24733
UL https://hdl.handle.net/10668/24733
LA en
DS RISalud
RD Apr 14, 2025