RT Journal Article
T1 Development and validation of a noninvasive prediction model for nonalcoholic steatohepatitis resolution after lifestyle intervention.
A1 Vilar-Gomez, Eduardo
A1 Yasells-Garcia, Ali
A1 Martinez-Perez, Yadina
A1 Calzadilla-Bertot, Luis
A1 Torres-Gonzalez, Ana
A1 Gra-Oramas, Bienvenido
A1 Gonzalez-Fabian, Licet
A1 Villa-Jimenez, Oscar
A1 Friedman, Scott L
A1 Diago, Moises
A1 Romero-Gomez, Manuel
AB Liver biopsy is the gold standard method to assess nonalcoholic steatohepatitis (NASH) resolution after therapeutic interventions. We developed and validated a simple and noninvasive scoring system to predict NASH resolution without fibrosis worsening after 1 year of lifestyle intervention. This was a prospective cohort study conducted in 261 patients with histologically proven NASH who were treated with lifestyle changes for 52 weeks and underwent a second liver biopsy to confirm NASH resolution. We divided the data into development (140 subjects) and validation (121 individuals) sets. NASH resolution occurred in 28% (derivation group) and 27% (validation group). At the multivariable analysis, weight loss (odds ratio [OR] = 2.75, 95% confidence interval [CI] 1.65-4.58; P  A noninvasive prediction model including weight loss, type 2 diabetes, alanine aminotransferase normalization, age, and a nonalcoholic fatty liver activity score ≥5 may be useful to identify NASH resolution in patients under lifestyle intervention. (Hepatology 2016;63:1875-1887).
YR 2016
FD 2016-03-10
LK http://hdl.handle.net/10668/9813
UL http://hdl.handle.net/10668/9813
LA en
DS RISalud
RD Apr 6, 2025