RT Journal Article
T1 No evidence of firstly acquired acute hepatitis C virus infection outbreak among HIV-infected patients from Southern Spain: a multicentric retrospective study from 2000-2014.
A1 Neukam, Karin
A1 Viciana, Pompeyo
A1 Ojeda-Burgos, Guillermo
A1 Delgado-Fernández, Marcial
A1 Ríos, María J
A1 Macías, Juan
A1 Merino, Dolores
A1 Collado, Antonio
A1 Téllez, Francisco
A1 Pineda, Juan A
K1 Hepatitis C
K1 HIV
K1 Homosexuality
K1 Epidemics
K1 Injecting drug use
K1 Infectious diseases
K1 Bilirrubina
K1 Coinfección
K1 Intervalos de confianza
K1 Epidemias
K1 Estudios de seguimiento
K1 Infecciones por Vih
K1 Homosexualidad
K1 Hepatitis c
K1 Inmunoglobulina G
K1 Incidencia
K1 Masculino
K1 Prevalencia
K1 Estudios retrospectivos
K1 España
K1 Seroconversión
AB BACKGROUNDAcute hepatitis C virus (HCV) infection (AHCVI) outbreaks have been described recently within defined areas worldwide among HIV-infected homosexual men. This study aims to describe the cumulative frequency and incidence of firstly acquired AHCVI in an HIV-infected population in Southern Spain.METHODSThis is a retrospective study conducted at the Infectious Diseases Units of eight hospitals in Andalusia, Southern Spain. Primary AHC was considered as HCV immunoglobulin G antibody seroconversion. The time of infection was considered the moment between the last negative and the first positive HCV antibody determination.RESULTSA total of 23 cases of primary AHCVI have been detected from 2000 to 2014. Incidence rates [IR; 95 % confidence interval (CI)] were 0.036 (2.272-0.054) per 100 person-years (py) in the overall population over a follow-up period of 64170 py. Of the 22 (95.7 %) male subjects, 21 (95.5 %) had acquired AHCVI by homosexual contact, the IR (95 % CI) was 0.039 (0.024-0.06) per 100 py in this subpopulation. There was no evidence of an increase of AHCVI IR. The incidence of AHCVI was slightly lower between 2000 and 2004 as compared to 2005-2009 [IR ratio (IRR) of 8.8 (95 % CI: 1.279-378.794; p = 0.01)] but reached a plateau afterwards [IRR between 2010 and 2014 versus 2005-2009: 0.727 (0.286-1.848; p = 0.5)]. The median (Q1-Q3) time between the last negative anti-HCV and the first positive anti-HCV determination was 4.7 (1.9-11.2) months. Peak (Q1-Q3) ALT and total bilirubin values during AHCVI were 496 (291-656) IU/mL and 1.15 (0.9-1.98) mg/dL, respectively.CONCLUSIONSIn contrast to what has been reported from other areas, the incidence of primary AHCVI in the HIV-infected population is stable in Southern Spain and there is no evidence of an epidemic, in spite of the high prevalence of HIV/HCV-coinfection in this area.
PB Biomed Central
YR 2016
FD 2016-09-15
LK http://hdl.handle.net/10668/2513
UL http://hdl.handle.net/10668/2513
LA en
NO Neukam K, Viciana P, Ojeda-Burgos G, Delgado-Fernández M, Ríos MJ, Macías J, et al. No evidence of firstly acquired acute hepatitis C virus infection outbreak among HIV-infected patients from Southern Spain: a multicentric retrospective study from 2000-2014. BMC Infect Dis.. 2016; 16:489
NO Journal Article;
DS RISalud
RD Apr 10, 2025