RT Journal Article
T1 Effect of lipid-lowering treatment in cardiovascular disease prevalence in familial hypercholesterolemia.
A1 Perez-Calahorra, Sofia
A1 Laclaustra, Martin
A1 Marco-Benedi, Victoria
A1 Lamiquiz-Moneo, Itziar
A1 Pedro-Botet, Juan
A1 Plana, Nuria
A1 Sanchez-Hernandez, Rosa M
A1 Amor, Antonio J
A1 Almagro, Fátima
A1 Fuentes, Francisco
A1 Suarez-Tembra, Manuel
A1 Civeira, Fernando
K1 Cardiovascular disease
K1 Familial hypercholesterolemia
K1 Lipid-lowering
K1 Statins
AB The impact on heterozygous familial hypercholesterolemia (HeFH) health led by high-intensity lipid-lowering therapy (HILLT) is unknown, and the question remains if there is still an unacceptably high residual risk to justify treatment with new lipid-lowering drugs. This observational, retrospective, multicenter, national study in Spain, whose information was obtained from a national dyslipemia registry, was designed to establish the current prevalence of cardiovascular disease (CVD) in HeFH and to define the impact of HILLT on CVD in this population. Odds were estimated using several logistic regression models with progressive adjustment. 1958 HeFH, mean age 49.3 ± 14.3 years, were included in the analysis. At inclusion in the registry, 295 patients (15.1%) had suffered CVD and 164 (55.6%) had suffered the first event before the onset lipid-lowering treatment. Exposition to treatment associated more than ten times lower odds for CVD than in subjects naïve to treatment (OR 0.085, 95% CI 0.063-0.114, p  Current prevalence of CVD among HeFH is one third of that reported before the statins era. Early initiation and prolonged lipid-lowering treatment was associated with a reduction in CVD. New cases of CVD, in spite of HILLT, appeared mostly among patients accumulating risk factors and probably they may be considered for further lipid-lowering drugs.
PB Elsevier
YR 2019
FD 2019-02-01
LK http://hdl.handle.net/10668/13654
UL http://hdl.handle.net/10668/13654
LA en
NO Perez-Calahorra S, Laclaustra M, Marco-Benedí V, Lamiquiz-Moneo I, Pedro-Botet J, Plana N, et al. Effect of lipid-lowering treatment in cardiovascular disease prevalence in familial hypercholesterolemia. Atherosclerosis. 2019 May;284:245-252
DS RISalud
RD Apr 12, 2025