RT Journal Article
T1 Editorial: Tumor Microenvironment and Cancer Cell Interactions in Solid Tumor Growth and Therapy Resistance.
A1 Ruocco, Maria Rosaria
A1 Lamberti, Annalisa
A1 Serrano, Maria Jose
A1 Fiume, Giuseppe
A1 Arcucci, Alessandro
K1 cancer immune response
K1 cutaneous melanoma
K1 therapy resistance
K1 tumor microenviroment
K1 tumour extracellular matrix
AB Solid tumour tissues contain a tumour microenvironment (TME) which influences tumour progression and therapy resistance (Romano et al., 2021). TME is a network including non-cancer stromal cells, extracellular matrix (ECM), growth factors, nutrients, blood and lymphatic vessels (Avagliano et al., 2020b), and its structure and components, depending on the type and location of the tumour, make each solid tumour unique (Granato et al., 2017; Avagliano et al., 2020a). Moreover, the TME plasticity leads to its evolution with disease and adaptation to cancer cell and environmental alterations. The components of TME by interacting with each other and with tumour cells generate a cancer niche that sustains immunosuppressive processes, drug resistance, cancer recurrence and dissemination that represent the main causes of cancer related deaths.
PB Frontiers Research Foundation
SN 2296-634X
YR 2022
FD 2022-03-23
LK http://hdl.handle.net/10668/20536
UL http://hdl.handle.net/10668/20536
LA en
NO Ruocco MR, Lamberti A, Serrano MJ, Fiume G, Arcucci A. Editorial: Tumor Microenvironment and Cancer Cell Interactions in Solid Tumor Growth and Therapy Resistance. Front Cell Dev Biol. 2022 Apr 8;10:896194
DS RISalud
RD Apr 10, 2025