RT Generic
T1 Regulation of Replication Fork Advance and Stability by Nucleosome Assembly
A1 Prado, Felix
A1 Maya, Douglas
K1 DNA replication
K1 chromatin assembly
K1 DNA damage tolerance
K1 replication fork stability
K1 homologous recombination
K1 Chromatin-remodeling complex
K1 Dna-polymerase-epsilon
K1 Newly synthesized histones
K1 H3 lysine-56 acetylation
K1 Loop binding-protein
K1 S-phase checkpoint
K1 Homologous recombination
K1 Cell-cycle
K1 Ubiquitin ligase
K1 Mms22l-nfkbil2 complex
AB The advance of replication forks to duplicate chromosomes in dividing cells requires the disassembly of nucleosomes ahead of the fork and the rapid assembly of parental and de novo histones at the newly synthesized strands behind the fork. Replication-coupled chromatin assembly provides a unique opportunity to regulate fork advance and stability. Through post-translational histone modifications and tightly regulated physical and genetic interactions between chromatin assembly factors and replisome components, chromatin assembly: (1) controls the rate of DNA synthesis and adjusts it to histone availability; (2) provides a mechanism to protect the integrity of the advancing fork; and (3) regulates the mechanisms of DNA damage tolerance in response to replication-blocking lesions. Uncoupling DNA synthesis from nucleosome assembly has deleterious effects on genome integrity and cell cycle progression and is linked to genetic diseases, cancer, and aging.
PB Mdpi
YR 2017
FD 2017-02-01
LK http://hdl.handle.net/10668/19258
UL http://hdl.handle.net/10668/19258
LA en
DS RISalud
RD Apr 4, 2025