RT Journal Article
T1 Proteins and pathways in atrial fibrillation and atrial cardiomyopathy underlying cryptogenic stroke.
A1 Palà, Elena
A1 Pagola, Jorge
A1 Juega, Jesus
A1 Francisco-Pascual, Jaume
A1 Penalba, Anna
A1 Rodriguez, Maite
A1 De Lera Alfonso, Mercedes
A1 Arenillas, Juan F
A1 Cabezas, Juan Antonio
A1 Moniche, Francisco
A1 de Torres, Reyes
A1 Perez-Sanchez, Soledad
A1 González-Alujas, Teresa
A1 Molina, Carlos A
A1 Bustamante, Alejandro
A1 Montaner, Joan
K1 Atrial cardiomyopathy
K1 Atrial fibrillation
K1 Atrial function
K1 Biomarkers
K1 Cryptogenic stroke
AB Atrial fibrillation (AF) is one of the most prevalent causes of cryptogenic stroke. Also, apart from AF itself, structural and remodelling changes in the atria might be an underlying cause of cryptogenic stroke. We aimed to discover circulating proteins and reveal pathways altered in AF and atrial cardiomyopathy, measured by left atrial volume index (LAVI) and peak atrial longitudinal strain (PALS), in patients with cryptogenic stroke. An aptamer array (including 1310 proteins) was measured in the blood of 20 cryptogenic stroke patients monitored during 28 days with a Holter device as a case-control study of the Crypto-AF cohort. Protein levels were compared between patients with (n = 10) and without AF (n = 10) after stroke, and the best candidates were tested in 111 patients from the same cohort (44 patients with AF and 67 without AF). In addition, in the first 20 patients, proteins were explored according to PALS and LAVI values. Forty-six proteins were differentially expressed in AF cases. Of those, four proteins were tested in a larger sample size. Only DPP7, presenting lower levels in AF patients, was further validated. Fifty-seven proteins correlated with LAVI, and 270 correlated with PALS. NT-proBNP was common in all the discovery analyses performed. Interestingly, many proteins and pathways were altered in patients with low PALS. Multiple proteins and pathways related to AF and atrial cardiomyopathy have been revealed. The role of DPP7 as a biomarker for stroke aetiology should be further explored. Moreover, the present study may be considered hypothesis-generating.
SN 2352-9067
YR 2022
FD 2022-03-07
LK http://hdl.handle.net/10668/22265
UL http://hdl.handle.net/10668/22265
LA en
DS RISalud
RD Apr 6, 2025