%0 Journal Article
%A Navarro-Compán, Victoria
%A Navarro-Sarabia, Federico
%T Safety and Efficacy of the Newer Biological Therapeutics in the Treatment of Rheumatoid Arthritis
%D 2011
%@ 1179-559X
%U http://hdl.handle.net/10668/505
%X Biological therapies have been a major advance in RA treatment. However, remission or response is not achieved in allpatients. Therefore, new drugs seem necessary. Most recent trials have focused in the development of three different groups of molecules:those against commercialized targets but minimizing side effects or improving administration, others molecules against newtargets, and a third group including small molecules. Some of them have been shown to be clinically efficacious and safe in RA patients,including: two new anti-TNF􀁁 therapies (golimumab and certolizumab pegol), three anti-CD (ocrelizumab, ofatumumab and a SMIP),subcutaneous abatacept, anti-IL17 therapy, tasocitinib and fostamatinib disodium. Therefore, a wide spectrum of new RA therapeutics are promising, but more studies are necessary to confirm these results.
%K New targets
%K Monoclonal antibodies
%K Small molecules
%K Rheumatoid arthritis
%K Efficacy
%K Safety
%K Nuevos objetivos
%K Anticuerpos monoclonales
%K Moléculas pequeñas
%K Artritis reumatoide
%K Eficacia
%K Seguridad
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