TY  - JOUR
AU  - Macías, Juan
AU  - Pinilla, Ana
AU  - Lao-Dominguez, Francisco A.
AU  - Corma, Anaïs
AU  - Contreras-Macias, Enrique
AU  - González-Serna, Alejandro
AU  - Gutierrez-Pizarraya, Antonio
AU  - Fernández-Fuertes, Marta
AU  - Morillo-Verdugo, Ramón
AU  - Trigo, Marta
AU  - Real, Luis M.
AU  - Pineda, Juan A.
PY  - 2020
DO  - 10.1038/s41598-020-78029-3
UR  - http://hdl.handle.net/10668/3438
T2  - Scientific Reports
AB  - The impact of drug-drug interactions (DDI) between ritonavir-boosted lopinavir (LPV-r) to treat patients with coronavirus disease 2019 (COVID-19) and commonly used drugs in clinical practice is not well-known. Thus, we evaluated the rate and severity...
LA  - en
PB  - Springer Nature
KW  - COVID-19
KW  - Antiviral agents
KW  - Drug combinations
KW  - Drug Interactions
KW  - Lopinavir
KW  - Ritonavir
KW  - Spain
KW  - Antivirales
KW  - Combinación de medicamentos
KW  - Interacciones farmacológicas
KW  - Inhibidores de proteasas
KW  - España
KW  - Medical Subject Headings::Persons::Persons::Age Groups::Adult::Aged
KW  - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Antiviral Agents
KW  - Medical Subject Headings::Diseases::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections
KW  - Medical Subject Headings::Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cross-Sectional Studies
KW  - Medical Subject Headings::Chemicals and Drugs::Pharmaceutical Preparations::Drug Combinations
KW  - Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Pharmacological Phenomena::Pharmacological Processes::Drug Interactions
KW  - Medical Subject Headings::Check Tags::Female
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
KW  - Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Pyrimidines::Pyrimidinones::Lopinavir
KW  - Medical Subject Headings::Check Tags::Male
KW  - Medical Subject Headings::Persons::Persons::Age Groups::Adult::Middle Aged
KW  - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Enzyme Inhibitors::Protease Inhibitors
KW  - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Sulfur Compounds::Thiazoles::Ritonavir
KW  - Medical Subject Headings::Geographical Locations::Geographic Locations::Europe::Spain
TI  - High rate of major drug-drug interactions of lopinavir-ritonavir for COVID-19 treatment
TY  - research article
ER  -