RT Journal Article
T1 The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients.
A1 Torres, Antoni
A1 Motos, Anna
A1 Riera, Jordi
A1 Fernández-Barat, Laia
A1 Ceccato, Adrián
A1 Pérez-Arnal, Raquel
A1 García-Gasulla, Dario
A1 Peñuelas, Oscar
A1 Lorente, José Angel
A1 Rodriguez, Alejandro
A1 de Gonzalo-Calvo, David
A1 Almansa, Raquel
A1 Gabarrús, Albert
A1 Menéndez, Rosario
A1 Bermejo-Martin, Jesús F
A1 Ferrer, Ricard
A1 Amaya Villar, Rosario
A1 Añón, José M
A1 Barberà, Carme
A1 Barberán, José
A1 Blandino Ortiz, Aaron
A1 Bustamante-Munguira, Elena
A1 Caballero, Jesús
A1 Carbajales, Cristina
A1 Carbonell, Nieves
A1 Catalán-González, Mercedes
A1 Galbán, Cristóbal
A1 Gumucio-Sanguino, Víctor D
A1 de la Torre, Maria Del Carmen
A1 Díaz, Emili
A1 Estella, Ángel
A1 Gallego, Elena
A1 García Garmendia, José Luis
A1 Garnacho-Montero, José
A1 Gómez, José M
A1 Huerta, Arturo
A1 Jorge García, Ruth Noemí
A1 Loza-Vázquez, Ana
A1 Marin-Corral, Judith
A1 Martínez de la Gándara, Amalia
A1 Martínez Varela, Ignacio
A1 López Messa, Juan
A1 M Albaiceta, Guillermo
A1 Novo, Mariana Andrea
A1 Peñasco, Yhivian
A1 Pozo-Laderas, Juan Carlos
A1 Ricart, Pilar
A1 Salvador-Adell, Inmaculada
A1 Sánchez-Miralles, Angel
A1 Sancho Chinesta, Susana
A1 Socias, Lorenzo
A1 Solé-Violan, Jordi
A1 Suares Sipmann, Fernando
A1 Tamayo Lomas, Luis
A1 Trenado, José
A1 Barbé, Ferran
A1 CIBERESUCICOVID Project (COV20/00110, ISCIII)
K1 COVID-19
K1 Coronavirus
K1 Mechanical ventilation
K1 SARS-CoV-2
K1 Ventilatory ratio
AB Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study is to investigate associations between mortality and variables measured during the first three days of mechanical ventilation in patients with COVID-19 intubated at ICU admission. Multicenter, observational, cohort study includes consecutive patients with COVID-19 admitted to 44 Spanish ICUs between February 25 and July 31, 2020, who required intubation at ICU admission and mechanical ventilation for more than three days. We collected demographic and clinical data prior to admission; information about clinical evolution at days 1 and 3 of mechanical ventilation; and outcomes. Of the 2,095 patients with COVID-19 admitted to the ICU, 1,118 (53.3%) were intubated at day 1 and remained under mechanical ventilation at day three. From days 1 to 3, PaO2/FiO2 increased from 115.6 [80.0-171.2] to 180.0 [135.4-227.9] mmHg and the ventilatory ratio from 1.73 [1.33-2.25] to 1.96 [1.61-2.40]. In-hospital mortality was 38.7%. A higher increase between ICU admission and day 3 in the ventilatory ratio (OR 1.04 [CI 1.01-1.07], p = 0.030) and creatinine levels (OR 1.05 [CI 1.01-1.09], p = 0.005) and a lower increase in platelet counts (OR 0.96 [CI 0.93-1.00], p = 0.037) were independently associated with a higher risk of death. No association between mortality and the PaO2/FiO2 variation was observed (OR 0.99 [CI 0.95 to 1.02], p = 0.47). Higher ventilatory ratio and its increase at day 3 is associated with mortality in patients with COVID-19 receiving mechanical ventilation at ICU admission. No association was found in the PaO2/FiO2 variation.
YR 2021
FD 2021-09-13
LK https://hdl.handle.net/10668/27771
UL https://hdl.handle.net/10668/27771
LA en
DS RISalud
RD Apr 5, 2025