RT Journal Article
T1 Co-infections and superinfections complicating COVID-19 in cancer patients: A multicentre, international study.
A1 Gudiol, C
A1 Dura-Miralles, X
A1 Aguilar-Company, J
A1 Hernandez-Jimenez, P
A1 Martinez-Cutillas, M
A1 Fernandez-Aviles, F
A1 Machado, M
A1 Vazquez, L
A1 Martin-Davila, P
A1 de-Castro, N
A1 Abdala, E
A1 Sorli, L
A1 Andermann, T M
A1 Marquez-Gomez, I
A1 Morales, H
A1 Gabilan, F
A1 Ayaz, C M
A1 Kayaaslan, B
A1 Aguilar-Guisado, M
A1 Herrera, F
A1 Royo-Cebrecos, C
A1 Peghin, M
A1 Gonzalez-Rico, C
A1 Goikoetxea, J
A1 Salgueira, C
A1 Silva-Pinto, A
A1 Gutierrez-Gutierrez, B
A1 Cuellar, S
A1 Haidar, G
A1 Maluquer, C
A1 Marin, M
A1 Pallares, N
A1 Carratala, J
K1 Neoplasms
K1 Coinfection
K1 Opportunistic Infections
K1 Infections
AB We aimed to describe the epidemiology, risk factors, and clinical outcomes of co-infections and superinfections in onco-hematological patients with COVID-19. International, multicentre cohort study of cancer patients with COVID-19. All patients were included in the analysis of co-infections at diagnosis, while only patients admitted at least 48 h were included in the analysis of superinfections. 684 patients were included (384 with solid tumors and 300 with hematological malignancies). Co-infections and superinfections were documented in 7.8% (54/684) and 19.1% (113/590) of patients, respectively. Lower respiratory tract infections were the most frequent infectious complications, most often caused by Streptococcus pneumoniae and Pseudomonas aeruginosa. Only seven patients developed opportunistic infections. Compared to patients without infectious complications, those with infections had worse outcomes, with high rates of acute respiratory distress syndrome, intensive care unit (ICU) admission, and case-fatality rates. Neutropenia, ICU admission and high levels of C-reactive protein (CRP) were independent risk factors for infections. Infectious complications in cancer patients with COVID-19 were lower than expected, affecting mainly neutropenic patients with high levels of CRP and/or ICU admission. The rate of opportunistic infections was unexpectedly low. The use of empiric antimicrobials in cancer patients with COVID-19 needs to be optimized.
PB Elsevier
YR 2021
FD 2021-07-22
LK http://hdl.handle.net/10668/18256
UL http://hdl.handle.net/10668/18256
LA en
NO Gudiol C, Durà-Miralles X, Aguilar-Company J, Hernández-Jiménez P, Martínez-Cutillas M, Fernandez-Avilés F, et al. Co-infections and superinfections complicating COVID-19 in cancer patients: A multicentre, international study. J Infect. 2021 Sep;83(3):306-313
NO This study was supported by the Spanish Plan Nacional de IDi 2013-2016, Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Economía, Industria y Competitividad, and the Spanish Network for Research in Infectious Diseases (REIPI grant: RD16/0016/0001). It was also co-financed by the European Development Regional Fund ‘A Way to Make Europe’, Operational Programme Smart Growth 2014-2020.
DS RISalud
RD Apr 7, 2025