TY - GEN AU - De Diego-Adelino, Javier AU - Crespo, Jose Manuel AU - Mora, Fernando AU - Neyra, Adrian AU - Iborra, Pedro AU - Gutierrez-Rojas, Luis AU - Salonia, Selman F. PY - 2021 DO - 10.1080/14740338.2022.2019705 SN - 1474-0338 UR - https://hdl.handle.net/10668/26044 T2 - Expert opinion on drug safety AB - Introduction Vortioxetine is a multimodal-acting antidepressant that provides improvements on cognitive function aside from antidepressants and anxiolytic effects. Vortioxetine has been found to be one of the most effective and best tolerated options... LA - en PB - Taylor & francis ltd KW - Antidepressant KW - cognition KW - efficacy KW - interactions KW - major depressive disorder KW - neurotransmission KW - pharmacology KW - safety KW - vortioxetine KW - Serotonin reuptake inhibitors KW - Multimodal antidepressant vortioxetine KW - Randomized controlled-trials KW - Emergent sexual dysfunction KW - Placebo-controlled trials KW - Substance use disorders KW - Inadequate response KW - Double-blind KW - 5-ht3 receptors KW - Open-label TI - Vortioxetine in major depressive disorder: from mechanisms of action to clinical studies. An updated review TY - review VL - 21 ER -