RT Journal Article
T1 Towards the Development of Novel Diclofenac Multicomponent Pharmaceutical Solids
A1 Javier Acebedo-Martinez, Francisco
A1 Alarcon-Payer, Carolina
A1 Maria Barrales-Ruiz, Helena
A1 Niclos-Gutierrez, Juan
A1 Dominguez-Martin, Alicia
A1 Choquesillo-Lazarte, Duane
K1 diclofenac
K1 nucleobases
K1 mechanochemical synthesis
K1 multicomponent materials
K1 pharmaceutical solid forms
K1 Antiinflammatory drug diclofenac
K1 Crystal-structures
K1 Co-crystals
K1 Solubility
K1 Cocrystals
K1 Coordination
K1 Acid
K1 Nucleobases
K1 Complexes
K1 Binding
AB Multicomponent pharmaceutical materials offer new opportunities to address drug physicochemical issues and to obtain improved drug formulation, especially on oral administration drugs. This work reports three new multicomponent pharmaceutical crystals of the non-steroidal anti-inflammatory drug diclofenac and the nucleobases adenine, cytosine, and isocytosine. They have been synthesized by mechanochemical methods and been characterized in-depth in solid-state by powder and single crystal X-ray diffraction, as well as other techniques such as thermal analyses and infrared spectroscopy. Stability and solubility tests were also performed on these materials. This work aimed to evaluate the physicochemical properties of these solid forms, which revealed thermal stability improvement. Dissociation of the new phases was observed in water, though. This fact is consistent with the reported observed layered structures and BFDH morphology calculations.
PB Mdpi
YR 2022
FD 2022-08-01
LK http://hdl.handle.net/10668/20951
UL http://hdl.handle.net/10668/20951
LA en
DS RISalud
RD Apr 6, 2025