RT Journal Article
T1 Gene co-expression architecture in peripheral blood in a cohort of remitted first-episode schizophrenia patients.
A1 Rodriguez, Natalia
A1 Gasso, Patricia
A1 Martinez-Pinteño, Albert
A1 Segura, Alex-Gonzalez
A1 Mezquida, Gisela
A1 Moreno-Izco, Lucia
A1 Gonzalez-Peñas, Javier
A1 Zorrilla, Iñaki
A1 Martin, Marta
A1 Rodriguez-Jimenez, Roberto
A1 Corripio, Iluminada
A1 Sarro, Salvador
A1 Ibañez, Angela
A1 Butjosa, Anna
A1 Contreras, Fernando
A1 Bioque, Miquel
A1 Cuesta, Manuel-Jesus
A1 Parellada, Mara
A1 Gonzalez-Pinto, Ana
A1 Berrocoso, Esther
A1 Bernardo, Miquel
A1 Mas, Sergi
K1 Signal transduction
K1 Biological phenomena
K1 Immunity
K1 Gene expression regulation
AB A better understanding of schizophrenia subtypes is necessary to stratify the patients according to clinical attributes. To explore the genomic architecture of schizophrenia symptomatology, we analyzed blood co-expression modules and their association with clinical data from patients in remission after a first episode of schizophrenia. In total, 91 participants of the 2EPS project were included. Gene expression was assessed using the Clariom S Human Array. Weighted-gene co-expression network analysis (WGCNA) was applied to identify modules of co-expressed genes and to test its correlation with global functioning, clinical symptomatology, and premorbid adjustment. Among the 25 modules identified, six modules were significantly correlated with clinical data. These modules could be clustered in two groups according to their correlation with clinical data. Hub genes in each group showing overlap with risk genes for schizophrenia were enriched in biological processes related to metabolic processes, regulation of gene expression, cellular localization and protein transport, immune processes, and neurotrophin pathways. Our results indicate that modules with significant associations with clinical data showed overlap with gene sets previously identified in differential gene-expression analysis in brain, indicating that peripheral tissues could reveal pathogenic mechanisms. Hub genes involved in these modules revealed multiple signaling pathways previously related to schizophrenia, which may represent the complex interplay in the pathological mechanisms behind the disease. These genes could represent potential targets for the development of peripheral biomarkers underlying illness traits in clinical remission stages after a first episode of schizophrenia.
PB Nature Publishing Group
YR 2022
FD 2022-02-01
LK http://hdl.handle.net/10668/19560
UL http://hdl.handle.net/10668/19560
LA en
NO Rodríguez N, Gassó P, Martínez-Pinteño A, Segura ÀG, Mezquida G, Moreno-Izco L, et al. Gene co-expression architecture in peripheral blood in a cohort of remitted first-episode schizophrenia patients. Schizophrenia (Heidelb). 2022 Apr 27;8(1):45
NO This study was supported by the Carlos III Healthcare Institute, the Spanish Ministry of Science, Innovation and Universities, the European Regional Development Fund (ERDF/FEDER) (PI08/0208, PI11/00325, and PI14/00612), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), CERCA Program, Catalan Government, the Secretariat of Universities and Research of the Department of Enterprise and Knowledge (2017SGR1562 and 2017SGR1355), and Institut de Neurociències, Universitat de Barcelona.
DS RISalud
RD Apr 7, 2025