RT Journal Article
T1 Microglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer's disease
A1 Guillot-Sestier, Marie-Victoire
A1 Araiz, Ana Rubio
A1 Mela, Virginia
A1 Gaban, Aline Sayd
A1 O'Neill, Eoin
A1 Joshi, Lisha
A1 Chouchani, Edward T.
A1 Mills, Evanna L.
A1 Lynch, Marina A.
K1 Microglial metabolism
K1 Sexual dimorphism
K1 Alzheimer’s disease
K1 Risk factors
K1 Amyloidosis
K1 Genes
K1 Microglía
K1 Metabolismo
K1 Características sexuales
K1 Enfermedad de Alzheimer
K1 Factores de riesgo
K1 Amiloidosis
AB Age and sex are major risk factors in Alzheimer's disease (AD) with a higher incidence of the disease in females. Neuroinflammation, which is a hallmark of AD, contributes to disease pathogenesis and is inexorably linked with inappropriate microglial activation and neurodegeneration. We investigated sex-related differences in microglia in APP/PS1 mice and in post-mortem tissue from AD patients. Changes in genes that are indicative of microglial activation were preferentially increased in cells from female APP/PS1 mice and cells from males and females were morphological, metabolically and functionally distinct. Microglia from female APP/PS1 mice were glycolytic and less phagocytic and associated with increased amyloidosis whereas microglia from males were amoeboid and this was also the case in post-mortem tissue from male AD patients, where plaque load was reduced. We propose that the sex-related differences in microglia are likely to explain, at least in part, the sexual dimorphism in AD.
PB Springer Nature
YR 2021
FD 2021-06-10
LK http://hdl.handle.net/10668/4035
UL http://hdl.handle.net/10668/4035
LA en
NO Guillot-Sestier MV, Araiz AR, Mela V, Gaban AS, O'Neill E, Joshi L, et al. Microglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer's disease. Commun Biol. 2021 Jun 10;4(1):711
DS RISalud
RD Apr 18, 2025