%0 Journal Article
%A Guillot-Sestier, Marie-Victoire
%A Araiz, Ana Rubio
%A Mela, Virginia
%A Gaban, Aline Sayd
%A O'Neill, Eoin
%A Joshi, Lisha
%A Chouchani, Edward T.
%A Mills, Evanna L.
%A Lynch, Marina A.
%T Microglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer's disease
%D 2021
%U http://hdl.handle.net/10668/4035
%X Age and sex are major risk factors in Alzheimer's disease (AD) with a higher incidence of the disease in females. Neuroinflammation, which is a hallmark of AD, contributes to disease pathogenesis and is inexorably linked with inappropriate microglial activation and neurodegeneration. We investigated sex-related differences in microglia in APP/PS1 mice and in post-mortem tissue from AD patients. Changes in genes that are indicative of microglial activation were preferentially increased in cells from female APP/PS1 mice and cells from males and females were morphological, metabolically and functionally distinct. Microglia from female APP/PS1 mice were glycolytic and less phagocytic and associated with increased amyloidosis whereas microglia from males were amoeboid and this was also the case in post-mortem tissue from male AD patients, where plaque load was reduced. We propose that the sex-related differences in microglia are likely to explain, at least in part, the sexual dimorphism in AD.
%K Microglial metabolism
%K Sexual dimorphism
%K Alzheimer’s disease
%K Risk factors
%K Amyloidosis
%K Genes
%K Microglía
%K Metabolismo
%K Características sexuales
%K Enfermedad de Alzheimer
%K Factores de riesgo
%K Amiloidosis
%~