RT Journal Article
T1 Impact of uterine manipulator on oncological outcome in endometrial cancer surgery.
A1 Padilla-Iserte, Pablo
A1 Lago, Víctor
A1 Tauste, Carmen
A1 Díaz-Feijoo, Berta
A1 Gil-Moreno, Antonio
A1 Oliver, Reyes
A1 Coronado, Pluvio
A1 Martín-Salamanca, María Belén
A1 Pantoja-Garrido, Manuel
A1 Marcos-Sanmartin, Josefina
A1 Gilabert-Estellés, Juan
A1 Lorenzo, Cristina
A1 Cazorla, Eduardo
A1 Roldán-Rivas, Fernando
A1 Rodríguez-Hernández, José Ramón
A1 Sánchez, Lourdes
A1 Muruzábal, Juan Carlos
A1 Hervas, David
A1 Domingo, Santiago
A1 Spanish Society of Gynecology and Obstetrics Spanish Investigational Network Gynecologic Oncology Group, 
K1 endometrial cancer
K1 minimally invasive surgery
K1 oncological safety
K1 overall survival
K1 recurrence
K1 recurrence-free survival
K1 uterine manipulator
AB There are limited data available to indicate whether oncological outcomes might be influenced by the uterine manipulator, which is used at the time of hysterectomy for minimally invasive surgery in patients with endometrial cancer. The current evidence derives from retrospective studies with limited sample sizes. Without substantial evidence to support its use, surgeons are required to make decisions about its use based only on their personal choice and surgical experience. To evaluate the use of the uterine manipulator on oncological outcomes after minimally invasive surgery, for apparent early-stage endometrial cancer. We performed a retrospective multicentric study to assess the oncological safety of uterine manipulator use in patients with apparent early-stage endometrial cancer, treated with minimally invasive surgery. The type of manipulator, surgical staging, histology, lymphovascular space invasion, International Federation of Gynecology and Obstetrics stage, adjuvant treatment, recurrence, and pattern of recurrence were evaluated. The primary objective was to determine the relapse rate. The secondary objective was to determine recurrence-free survival, overall survival, and the pattern of recurrence. A total of 2661 women from 15 centers were included; 1756 patients underwent hysterectomy with a uterine manipulator and 905 without it. Both groups were balanced with respect to histology, tumor grade, myometrial invasion, International Federation of Gynecology and Obstetrics stage, and adjuvant therapy. The rate of recurrence was 11.69% in the uterine manipulator group and 7.4% in the no-manipulator group (P In this study, the use of a uterine manipulator was associated with a worse oncological outcome in patients with uterus-confined endometrial cancer (International Federation of Gynecology and Obstetrics I-II) who underwent minimally invasive surgery. Prospective trials are essential to confirm these results.
YR 2020
FD 2020-07-18
LK http://hdl.handle.net/10668/15966
UL http://hdl.handle.net/10668/15966
LA en
DS RISalud
RD Apr 8, 2025