RT Journal Article
T1 Respiratory infection in congenital cardiac disease. Hospitalizations in young children in Spain during 2004 and 2005: the CIVIC Epidemiologic Study.
A1 Medrano, Constancio
A1 Garcia-Guereta, Luis
A1 Grueso, Josefina
A1 Insa, Beatriz
A1 Ballesteros, Fernando
A1 Casaldaliga, Jaume
A1 Cuenca, Victorio
A1 Escudero, Fuensanta
A1 Garcia de la Calzada, Lola
A1 Luis, Maite
A1 Luque, Manuel
A1 Mendoza, Alberto
A1 Prada, Fredy
A1 Rodríguez, Maria del Mar
A1 Suarez, Pedro
A1 Quero, Concepción
A1 Guilera, Magda
K1 Infant
K1 Congenitally malformed hearts
K1 Haemodynamically significant
K1 respiratory syncytial virus
K1 Trisomy 21
K1 Infecciones por Haemophilus
K1 Cardiopatías congénitas
K1 Infecciones por virus sincitial respiratorio
K1 Estudios de cohortes
K1 España
AB OBJECTIVESTo evaluate the rate of hospitalization for acute respiratory tract infection in children less than 24 months with haemodynamically significant congenital cardiac disease, and to describe associated risk factors, preventive measures, aetiology, and clinical course.MATERIALS AND METHODSWe followed 760 subjects from October 2004 through April 2005 in an epidemiological, multicentric, observational, follow-up, prospective study involving 53 Spanish hospitals.RESULTSOf our cohort, 79 patients (10.4%, 95% CI: 8.2%-12.6%) required a total of 105 admissions to hospital related to respiratory infections. The incidence rate was 21.4 new admissions per 1000 patients-months. Significant associated risk factors for hospitalization included, with odds ratios and 95% confidence intervals shown in parentheses: 22q11 deletion (8.2, 2.5-26.3), weight below the 10th centile (5.2, 1.6-17.4), previous respiratory disease (4.5, 2.3-8.6), incomplete immunoprophylaxis against respiratory syncytial virus (2.2, 1.2-3.9), trisomy 21 (2.1, 1.1-4.2), cardiopulmonary bypass (2.0, 1.1-3.4), and siblings aged less than 11 years old (1.7, 1.1-2.9). Bronchiolitis (51.4%), upper respiratory tract infections (25.7%), and pneumonia (20%) were the main diagnoses. An infectious agent was found in 37 cases (35.2%): respiratory syncytial virus in 25, Streptococcus pneumoniae in 5, and Haemophilus influenzae in 4. The odds ratio for hospitalization due to infection by the respiratory syncytial virus increases by 3.05 (95% CI: 2.14 to 4.35) in patients with incomplete prophylaxis. The median length of hospitalization was 7 days. In 18 patients (17.1%), the clinical course of respiratory infection was complicated and 2 died.CONCLUSIONSHospital admissions for respiratory infection in young children with haemodynamically significant congenital cardiac disease are mainly associated with non-cardiac conditions, which may be genetic, malnutrition, or respiratory, and to cardiopulmonary bypass. Respiratory syncytial virus was the most commonly identified infectious agent. Incomplete immunoprophylaxis against the virus increased the risk of hospitalization.
PB Cambridge University Press
SN 1047-9511
YR 2007
FD 2007-08
LK http://hdl.handle.net/10668/1313
UL http://hdl.handle.net/10668/1313
LA en
NO Medrano C, Garcia-Guereta L, Grueso J, Insa B, Ballesteros F, Casaldaliga J, et al. Respiratory infection in congenital cardiac disease. Hospitalizations in young children in Spain during 2004 and 2005: the CIVIC Epidemiologic Study. Cardiol Young. 2007; 17(4):360-71
NO Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 8, 2025