RT Journal Article
T1 Exosome: A New Player in Translational Nanomedicine.
A1 Aheget, Houssam
A1 Tristán-Manzano, María
A1 Mazini, Loubna
A1 Cortijo-Gutierrez, Marina
A1 Galindo-Moreno, Pablo
A1 Herrera, Concha
A1 Martin, Francisco
A1 Marchal, Juan Antonio
A1 Benabdellah, Karim
K1 CARs
K1 cancer
K1 exosomes
K1 gene editing
K1 immunotherapy
K1 liquid biopsies
AB Exosomes are extracellular vesicles released by the vast majority of cell types both in vivo and ex vivo, upon the fusion of multivesicular bodies (MVBs) with the cellular plasma membrane. Two main functions have been attributed to exosomes: their capacity to transport proteins, lipids and nucleic acids between cells and organs, as well as their potential to act as natural intercellular communicators in normal biological processes and in pathologies. From a clinical perspective, the majority of applications use exosomes as biomarkers of disease. A new approach uses exosomes as biologically active carriers to provide a platform for the enhanced delivery of cargo in vivo. One of the major limitations in developing exosome-based therapies is the difficulty of producing sufficient amounts of safe and efficient exosomes. The identification of potential proteins involved in exosome biogenesis is expected to directly cause a deliberate increase in exosome production. In this review, we summarize the current state of knowledge regarding exosomes, with particular emphasis on their structural features, biosynthesis pathways, production techniques and potential clinical applications.
SN 2077-0383
YR 2020
FD 2020-07-26
LK https://hdl.handle.net/10668/28422
UL https://hdl.handle.net/10668/28422
LA en
DS RISalud
RD Apr 18, 2025