RT Generic
T1 Mechanics and self-organization in tissue development
A1 Gomez-Galvez, Pedro
A1 Anbari, Samira
A1 Escudero, Luis M.
A1 Buceta, Javier
K1 Self-organization
K1 Cell packing
K1 Cell sorting
K1 Traveling waves
K1 Epithelia
K1 ERK
K1 Developmental mechanics
K1 Developmental mechanisms
K1 Differential adhesion hypothesis
K1 Cell-cell interactions
K1 Dissociated cells
K1 Compartment boundaries
K1 Intercellular-adhesion
K1 Voronoi-tessellation
K1 Pattern-formation
K1 Cortical tension
K1 Model
K1 Morphogenesis
AB Self-organization is an all-important feature of living systems that provides the means to achieve specialization and functionality at distinct spatio-temporal scales. Herein, we review this concept by addressing the packing organization of cells, the sorting/compartmentalization phenomenon of cell populations, and the propagation of organizing cues at the tissue level through traveling waves. We elaborate on how different theoretical models and tools from Topology, Physics, and Dynamical Systems have improved the understanding of self-organization by shedding light on the role played by mechanics as a driver of morphogenesis. Altogether, by providing a historical perspective, we show how ideas and hypotheses in the field have been revisited, developed, and/or rejected and what are the open questions that need to be tackled by future research.
PB Academic press ltd- elsevier science ltd
SN 1084-9521
YR 2021
FD 2021-12-08
LK http://hdl.handle.net/10668/18886
UL http://hdl.handle.net/10668/18886
LA en
DS RISalud
RD Apr 6, 2025