TY - JOUR AU - Vargas-Soria, Maria AU - Ramos-Rodriguez, Juan Jose AU - Del Marco, Angel AU - Hierro-Bujalance, Carmen AU - Carranza-Naval, Maria Jose AU - Calvo-Rodriguez, Maria AU - van Veluw, Susanne J AU - Stitt, Alan W AU - Simo, Rafael AU - Bacskai, Brian J AU - Infante-Garcia, Carmen AU - Garcia-Alloza, Monica PY - 2022 DO - 10.1186/s12987-022-00380-6 UR - http://hdl.handle.net/10668/20335 T2 - Fluids and barriers of the CNS AB - While aging is the main risk factor for Alzheimer´s disease (AD), emerging evidence suggests that metabolic alterations such as type 2 diabetes (T2D) are also major contributors. Indeed, several studies have described a close relationship between AD... LA - en PB - BioMed Central KW - Alzheimer’s disease KW - Amyloid KW - Matrix metalloproteinases KW - Multiphoton microscopy KW - Oxidative stress KW - Prediabetes KW - Type 2 diabetes KW - Animals KW - Mice KW - Alzheimer disease KW - Disease models, animal KW - Diabetes mellitus, type 2 KW - Prediabetic state KW - Cerebral amyloid angiopathy KW - Amyloid beta-peptides KW - Plaque, amyloid KW - Brain KW - Matrix metalloproteinases TI - Accelerated amyloid angiopathy and related vascular alterations in a mixed murine model of Alzheimer´s disease and type two diabetes. TY - research article VL - 19 ER -