RT Journal Article
T1 MUFAs in High-Fat Diets Protect against Obesity-Induced Bias of Hematopoietic Cell Lineages.
A1 Lemus-Conejo, Ana
A1 Medrano, Mayte
A1 Lopez, Sergio
A1 Millan-Linares, Maria C
A1 Rosillo, Maria A
A1 Perez-Simon, Jose A
A1 Muriana, Francisco J G
A1 Abia, Rocio
K1 MUFAs
K1 dietary fatty acids
K1 hematopoiesis
K1 obesity
K1 progenitor cells
K1 stem cells
AB The role of dietary fatty acids in the generation of bone marrow (BM) immune cells and their trafficking to extramedullary compartments in the obesity is not yet fully understood. C57BL/6J mice are randomly assigned to isocaloric high-fat diets (HFDs) formulate with dietary fats rich in saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs) or MUFAs fortified with eicosapentaenoic and docosahexaenoic acids for 20 weeks, followed by profiling of the obese metabolic phenotype and immunophenotypic features of immune cells in blood, spleen, and BM. All HFDs induce an obese phenotype, but it becomes largely less disruptive after the HFDs are enriched in MUFAs, which also induce signs of granulopoiesis and an expansion of long-term hematopoietic stem and granulocyte-macrophage progenitor cells in BM. In contrast, a HFD enriched in SFAs disturbs the fitness of medullary lymphocytes and promotes monopoiesis in favor of pro-inflammatory activated subsets. The reshaping of the fatty acid pools with MUFAs from the diet serves to manipulate the generation and trafficking of immune cells that are biased during obesity. These findings reveal a novel strategy by which dietary MUFAs may be instrumental in combating HFD-induced dysfunctional immune systems.
YR 2021
FD 2021-06-24
LK http://hdl.handle.net/10668/18002
UL http://hdl.handle.net/10668/18002
LA en
DS RISalud
RD Apr 6, 2025