RT Journal Article
T1 Incorporation of Elastin to Improve Polycaprolactone-Based Scaffolds for Skeletal Muscle via Electrospinning
A1 Perez-Puyana, Victor
A1 Villanueva, Paula
A1 Jiménez-Rosado, Mercedes
A1 de la Portilla, Fernando
A1 Romero, Alberto
K1 Elastin
K1 Electrospinning
K1 Scaffolds
K1 Skeletal muscle cells
K1 Regeneration
K1 Elastina
K1 Células del músculo esquelético
K1 Regeneración
K1 Andamios del tejido
K1 Ensayo de materiales
AB Skeletal muscle regeneration is increasingly necessary, which is reflected in the increasing number of studies that are focused on improving the scaffolds used for such regeneration, as well as the incubation protocol. The main objective of this work was to improve the characteristics of polycaprolactone (PCL) scaffolds by incorporating elastin to achieve better cell proliferation and biocompatibility. In addition, two cell incubation protocols (with and without dynamic mechanical stimulation) were evaluated to improve the activity and functionality yields of the regenerated cells. The results indicate that the incorporation of elastin generates aligned and more hydrophilic scaffolds with smaller fiber size. In addition, the mechanical properties of the resulting scaffolds make them adequate for use in both bioreactors and patients. All these characteristics increase the biocompatibility of these systems, generating a better interconnection with the tissue. However, due to the low maturation achieved in biological tests, no differences could be found between the incubation with and without dynamic mechanical stimulation.
PB MDPI
YR 2021
FD 2021-05-06
LK http://hdl.handle.net/10668/3870
UL http://hdl.handle.net/10668/3870
LA en
NO Perez-Puyana V, Villanueva P, Jiménez-Rosado M, de la Portilla F, Romero A. Incorporation of Elastin to Improve Polycaprolactone-Based Scaffolds for Skeletal Muscle via Electrospinning. Polymers (Basel). 2021 May 6;13(9):1501
DS RISalud
RD Apr 11, 2025