TY  - JOUR
AU  - Di Zeo-Sánchez, Daniel E
AU  - Segovia-Zafra, Antonio
AU  - Matilla-Cabello, Gonzalo
AU  - Pinazo-Bandera, José M
AU  - Andrade, Raúl J
AU  - Lucena, M Isabel
AU  - Villanueva-Paz, Marina
PY  - 2022
DO  - 10.1080/17425255.2022.2122810
UR  - http://hdl.handle.net/10668/19691
T2  - Expert opinion on drug metabolism & toxicology
AB  - Idiosyncratic drug-induced liver injury (iDILI) is a challenging and unpredictable multifactorial condition. At present, validated preclinical models for the prediction of the hepatotoxic potential of a given drug are scarce. This review intends to...
LA  - en
KW  - DILI
KW  - Hepatotoxicity
KW  - iDILI
KW  - immune response
KW  - mechanisms
KW  - mitochondrial damage
KW  - oxidative stress
KW  - preclinical model
KW  - prediction
KW  - Animals
KW  - Biomarkers
KW  - Chemical and Drug Induced Liver Injury
KW  - Drug-Related Side Effects and Adverse Reactions
KW  - Hepatocytes
KW  - Humans
KW  - Liver
KW  - Mice
TI  - Modeling drug-induced liver injury: current status and future prospects.
TY  - research article
VL  - 18
ER  -